Diagnostic accuracy of 18F-FDG-PET in abdominal sepsis in rats
Acta cir. bras
;
35(5): e202000505, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1130643
ABSTRACT
Abstract Purpose The objective of this study was to investigate the accuracy of 18F-FDG-PET in the diagnosis of multibacterial abdominal sepsis by cecum ligation and puncture (CLP) in rats. Methods Adult Wistar rats ( Rattus norvegicus ), weighing 227±35g, were allocated into a sepsis group by CLP (n=10) and sham group (n=10). 18F-FDG-PET using microPET was performed on all rats after 24 hours. Results All animals survived for postoperative 24h. The abdomen/liver ratio of the standardized uptake value (SUV) percentage was significantly higher in the sepsis group than in the sham (p=0.004). The ROC curve showed an accuracy of 18F-FDG-PET to detect abdominal sepsis of 88.9% (p=0.001), sensitivity of 90% and specificity of 88.9%. When a cut-off point of 79% of the ratio between the SUV on the abdominal region and liver was established, the sensitivity was 90%, specificity of 88.9%; positive and negative predictive values of 90.0% and 88.9%, respectively. Conclusions The diagnostic accuracy of 18F-FDG-PET in rats with abdominal sepsis was significantly high. It was also demonstrated the predictive ability of the abdomen/liver SUV ratio to diagnose abdominal sepsis. These findings may have implications for the clinical setting, locating septic foci with PETscan.
Full text:
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Index:
LILACS (Americas)
Main subject:
Sepsis
/
Radiopharmaceuticals
/
Fluorodeoxyglucose F18
/
Positron-Emission Tomography
/
Intraabdominal Infections
Type of study:
Diagnostic study
/
Prognostic study
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UFRN/BR
/
Universidade Federal do Rio Grande do Norte/BR
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