Prevention of bone infection after open fracture using a chitosan with ciprofloxacin implant in animal model
Acta cir. bras
;
35(8): e202000803, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1130672
ABSTRACT
Abstract Purpose To evaluate different concentrations of ciprofloxacin to prevent infection after open fracture contaminated with S. aureus in rats using absorbable local delivery system. Methods Fifty-two Wistar rats were assigned to six groups. After 4 weeks, all animals underwent 99mTc-ceftizoxima scintigraphy evaluation, callus formation measurement and histological analysis. ANOVA, t-Student and Kruskal Wallis were used for quantitative variables statistical analysis, whereas qui square and exact Fisher were used for qualitative variables. Results Treatment using 25% and 50% of ciprofloxacin incorporated at the fracture fixation device were effective in preventing bone infection compared to control group (p<0.05). Chitosan were not effective in preventing bone infection when used alone compared to control group (p>0.05). Histological findings demonstrated bone-healing delay with 50% of ciprofloxacin. No difference in callus formation were observed (p>0.05). Conclusion Local delivery treatment for contaminated open fracture using chitosan with ciprofloxacin is effective above 25%.
Full text:
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Index:
LILACS (Americas)
Main subject:
Ciprofloxacin
/
Infection Control
/
Fracture Healing
/
Chitosan
/
Femoral Fractures
Type of study:
Prognostic study
/
Qualitative research
Limits:
Animals
/
Humans
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UFMG/BR
/
Universidade Federal de Minas Gerais/BR
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