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Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score
Reis, Alex Domingos dos; Mudinutti, Cristiane; Peigo, Murilo de Freitas; Leon, Lucas Lopes; Costallat, Lilian Tereza Lavras; Rossi, Claudio Lucio; Costa, Sandra Cecília Botelho; Bonon, Sandra Helena Alves.
  • Reis, Alex Domingos dos; State University of Campinas. School of Medical Sciences. Laboratory of Virology. Campinas. BR
  • Mudinutti, Cristiane; State University of Campinas. School of Medical Sciences. Laboratory of Virology. Campinas. BR
  • Peigo, Murilo de Freitas; State University of Campinas. School of Medical Sciences. Laboratory of Virology. Campinas. BR
  • Leon, Lucas Lopes; State University of Campinas. School of Medical Sciences. Laboratory of Virology. Campinas. BR
  • Costallat, Lilian Tereza Lavras; State University of Campinas. School of Medical Sciences. Discipline of Rheumatology. Campinas. BR
  • Rossi, Claudio Lucio; State University of Campinas. School of Medical Sciences. Department of Clinical Pathology. Campinas. BR
  • Costa, Sandra Cecília Botelho; State University of Campinas. School of Medical Sciences. Laboratory of Virology. Campinas. BR
  • Bonon, Sandra Helena Alves; State University of Campinas. School of Medical Sciences. Laboratory of Virology. Campinas. BR
Adv Rheumatol ; 60: 42, 2020. tab
Article in English | LILACS | ID: biblio-1130805
ABSTRACT
Abstract

Background:

Human herpesviruses (HHVs) are responsible for a significant number of clinical manifestations in systemic lupus erythematous (SLE) patients. The aim of this study was to determine the frequency of active HHV infections in SLE patients and correlating them with disease activity.

Methods:

Serum samples were collected from 71 SLE patients and their DNAs were extracted and analyzed to detect HHV-DNA viruses using the nucleic acid amplification technique.

Results:

Fifteen out of the 71 (21.1%) patients tested positive for the HHV-DNA virus. Of them, 11/15 HHV-DNA-positive patients (73.3%) had SLE activity index (SLEDAI - Systemic Lupus Erythematosus Disease Activity Index) ≥8 (p = 0.0001). Active HCMV infection was the mostly frequently observed infection, occurring in 6/15 patients (40%). The frequencies of other active viral infections were 22% for HSV-1, 16.7% for HHV-7, and 5.5% for HSV-2. Viral coinfection (two or more viruses detected in the same sample) occurred in three patients (16.7%). Active HHV infections in SLE patients are more frequent in those with active SLE (≥8), who is at high risk of HHV reactivation and HCMV disease.

Conclusion:

Viral surveillance is important to identify active HHV infections that can cause clinical symptoms and other complication in SLE patients.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Herpesviridae Infections / Nucleic Acid Amplification Techniques / Lupus Erythematosus, Systemic Type of study: Prognostic study Limits: Humans Language: English Journal: Adv Rheumatol Journal subject: Artrite / Reumatologia Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: State University of Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Herpesviridae Infections / Nucleic Acid Amplification Techniques / Lupus Erythematosus, Systemic Type of study: Prognostic study Limits: Humans Language: English Journal: Adv Rheumatol Journal subject: Artrite / Reumatologia Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: State University of Campinas/BR