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Worse survival of invasive melanoma patients in men and de novo lesions
Department of DermatologyGiavina-Bianchi, Mara Huffenbaecher; Department of DermatologyFesta-Neto, Cyro; Department of DermatologySanches, Jose Antonio; Teixeira, Monica La Porte; Waldvogel, Bernadette Cunha.
  • Department of DermatologyGiavina-Bianchi, Mara Huffenbaecher; Universidade de São Paulo. Faculdade de Medicina. Department of DermatologyGiavina-Bianchi, Mara Huffenbaecher. São Paulo. BR
  • Department of DermatologyFesta-Neto, Cyro; Universidade de São Paulo. Faculdade de Medicina. Department of DermatologyFesta-Neto, Cyro. São Paulo. BR
  • Department of DermatologySanches, Jose Antonio; Universidade de São Paulo. Faculdade de Medicina. Department of DermatologySanches, Jose Antonio. São Paulo. BR
  • Teixeira, Monica La Porte; Fundação Sistema Estadual de Análise de Dados. Department of Data Information Analysis and Dissemination. São Paulo. BR
  • Waldvogel, Bernadette Cunha; Fundação Sistema Estadual de Análise de Dados. Department of Data Information Analysis and Dissemination. São Paulo. BR
An. bras. dermatol ; 95(2): 158-164, Mar.-Apr. 2020. tab
Article in English | LILACS, ColecionaSUS | ID: biblio-1130841
ABSTRACT
Abstract

Background:

The incidence and mortality of melanoma is increasing in many countries, including Brazil. Survival studies are still scarce in our country, but much needed to know and address this problem better.

Objective:

To analyze the disease-specific survival of patients with invasive melanoma and to correlate it with clinical and histopathological variables.

Methods:

Retrospective cohort analysis of 565 cases of invasive melanoma in a tertiary hospital with the objective of testing variables that could be associated with a worse prognosis, such as gender, phototype, thickness, histological type and presence of pre-existing clinical lesion at the site of the tumor.

Results:

The worst survival rates were significantly associated with thicker tumors (p < 0.001), male sex (p = 0.014), high phototype (p = 0.047), nodular melanoma (p = 0.024) and "de novo" lesions (p = 0.005). When all variables were adjusted for melanoma thickness, male patients (p = 0.011) and "de novo" melanomas (p = 0.025) remained associated with worse survival. Study

limitations:

Retrospective study of a single tertiary hospital.

Conclusions:

Although the causes are still unknown, melanoma-specific survival was statistically worse for males and for "de novo" melanomas even after adjustment of tumor thickness.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Skin Neoplasms / Melanoma Type of study: Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: South America / Brazil Language: English Journal: An. bras. dermatol Year: 2020 Type: Article Institution/Affiliation country: Fundação Sistema Estadual de Análise de Dados/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Skin Neoplasms / Melanoma Type of study: Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: South America / Brazil Language: English Journal: An. bras. dermatol Year: 2020 Type: Article Institution/Affiliation country: Fundação Sistema Estadual de Análise de Dados/BR / Universidade de São Paulo/BR