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Comparison of basal cell carcinoma subtypes observed in preoperative biopsy and Mohs micrographic surgery
Dermatology ServiceCerci, Felipe Bochnia; Dermatology ServiceKubo, Elisa Mayumi; Werner, Betina.
  • Dermatology ServiceCerci, Felipe Bochnia; Universidade Federal do Paraná. Hospital de Clínicas. Dermatology ServiceCerci, Felipe Bochnia. Curitiba. BR
  • Dermatology ServiceKubo, Elisa Mayumi; Universidade Federal do Paraná. Hospital de Clínicas. Dermatology ServiceKubo, Elisa Mayumi. Curitiba. BR
  • Werner, Betina; Universidade Federal do Paraná. Postgraduate Program in Internal Medicine and Health Sciences. Curitiba. BR
An. bras. dermatol ; 95(5): 594-601, Sept.-Oct. 2020. graf
Article in English | LILACS, ColecionaSUS | ID: biblio-1130954
ABSTRACT
Abstract

Background:

The treatment of basal cell carcinoma depends on its histological subtype. Therefore, a biopsy should be performed before definitive treatment. However, as the biopsy is only a sample of the tumor, it does not always shows every histological subtype present in the neoplasm. Few studies have compared the histological findings of biopsies with the findings of Mohs micrographic surgery. By evaluating the totality of the peripheral margins, in addition to sampling large tumor areas, this technique provides a more representative amount of tissue than preoperative biopsy.

Objectives:

a) Determine the agreement between the histological subtype of basal cell carcinoma from punch biopsy and the findings of Mohs surgery; b) To assess, among the discordant cases, the prevalence of non-aggressive tumors in the preoperative biopsy that were reclassified as aggressive by Mohs surgery.

Methods:

Retrospective analysis of 79 cases of basal cell carcinomas submitted to punch biopsy and subsequent Mohs surgery.

Results:

The agreement between the classification of the subtypes in the biopsy and in Mohs surgery was 40.5%. Punch biopsy was able to predict the most aggressive basal cell carcinoma growth pattern in 83% of cases. Study

limitations:

Retrospective nature, sample size, and biopsies performed by different professionals.

Conclusions:

The agreement between the histopathological subtypes of basal cell carcinoma as seen in preoperative biopsy and Mohs surgery was low. However, preoperative biopsy presented good accuracy (83%) in detecting aggressive histopathological subtypes.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Skin Neoplasms / Carcinoma, Basal Cell Type of study: Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: An. bras. dermatol Year: 2020 Type: Article Institution/Affiliation country: Universidade Federal do Paraná/BR

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Full text: Available Index: LILACS (Americas) Main subject: Skin Neoplasms / Carcinoma, Basal Cell Type of study: Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: An. bras. dermatol Year: 2020 Type: Article Institution/Affiliation country: Universidade Federal do Paraná/BR