Cholestatic syndrome as initial manifestation of pancreatic metastasis of papillary thyroid carcinoma: case report and review
Arch. endocrinol. metab. (Online)
;
64(2): 179-184, Mar.-Apr. 2020. tab
Article
in English
| LILACS
| ID: biblio-1131073
ABSTRACT
SUMMARY Most papillary thyroid carcinomas (PTC) harbor excellent prognosis. Although rare, distant metastases normally occur in lungs and/or bones. Here we describe a rare case of pancreatic metastasis presenting with rapid onset cholestatic syndrome. A literature review was also performed. A 73-year-old man with a high risk PTC was submitted to total thyroidectomy (TT) followed by radioiodine therapy. After initial therapy, he persisted with progressive rising serum thyroglobulin levels but with no evidence of structural disease. Recently, the patient presented with a rapid onset and progressive cholestatic syndrome. A 4 cm lesion in pancreas was identified, with echoendoscopy fine-needle aspiration biopsy (FNAB) confirming a pancreatic metastasis from PTC. The patient was submitted to a successful pancreaticoduodenectomy. Pancreatic metastases of PTC are rare and few long-term follow-up data are available to guide management. Fourteen cases were former reported, mean age was 65.7 years-old with mean time between PTC and pancreatic metastasis diagnosis of 7.9 years. Nine of them had another distant metastasis, nine were diagnosed by FNAB and just two received sorafenib.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pancreatic Neoplasms
/
Thyroid Neoplasms
/
Cholestasis
/
Thyroid Cancer, Papillary
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Arch. endocrinol. metab. (Online)
Journal subject:
Endocrinology
/
Metabolism
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital Central da Polícia Militar/BR
/
Instituto Nacional de Câncer José Alencar Gomes da Silva/BR
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