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Intrathyroid injection of dexamethasone inhibits Th2 cells in Graves disease
He, Ke; Jiang, Peng; Liu, Bing-li; Liu, Xiao-mei; Mao, Xiao-ming; Hu, Yun.
  • He, Ke; Nanjing University of Chinese Medicine. Wuxi Hospital of Traditional Chinese Medicine. Department of Endocrinology. Wuxi. CN
  • Jiang, Peng; Nanjing Medical University. Nanjing First Hospital. Department of Thyroid and Breast Surgery. Nanjing. CN
  • Liu, Bing-li; Nanjing Medical University. Nanjing First Hospital. Department of Endocrinology. Nanjing. CN
  • Liu, Xiao-mei; Nanjing Medical University. Nanjing First Hospital. Department of Endocrinology. Nanjing. CN
  • Mao, Xiao-ming; Nanjing Medical University. Nanjing First Hospital. Department of Endocrinology. Nanjing. CN
  • Hu, Yun; Nanjing Medical University. Nanjing First Hospital. Department of Endocrinology. Nanjing. CN
Arch. endocrinol. metab. (Online) ; 64(3): 243-250, May-June 2020. tab, graf
Article in English | LILACS | ID: biblio-1131091
ABSTRACT
ABSTRACT Objective Intrathyroid injection of dexamethasone (IID) was used for decrease the relapse rate of hyperthyroidism in the treatment of Graves' disease (GD), but the mechanism is still unclear. We aimed to explore the effect of IID on T help (Th)1/Th2 cells and their chemokine in patients with GD. Subjects and methods A total of 42 patients with GD who were euthyroidism by methimazole were randomly divided into IID group (n = 20) and control group (n = 22). Thyroid function and associated antibody, Th1/Th2 cells proportion, serum CXCL10 and CCL2 levels, and CXCR3/CCR2 mRNA expression in peripheral blood mononuclear cells before and after 3-month IID treatment were tested by chemiluminescence assay, Flow cytometry, ELISA, and real-time PCR, respectively. Thyroid follicular cells were stimulated by IFN-γ and TNF-α and treated with dexamethasone in vitro. CXCL10 and CCL2 levels in supernatant were determined. Results After 3-month therapy, the proportion of Th2 cells and serum CCL2 levels, as well as TPOAb, TRAb levels and thyroid volume decreased in IID group (p < 0.05). However, the proportion of Th1 and CXCL10 levels had no change in IID group and control (p > 0.05). The CXCR3/CCR2 ratio had no change in both groups (p > 0.05). Conclusion IID therapy could inhibit peripheral Th2 cells via decreasing CCL2 level in peripheral blood, and this result partly explain the effects of IID therapy on prevention of relapse of GD. Arch Endocrinol Metab. 2020;64(3)243-50
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Dexamethasone / Graves Disease / Th2 Cells / Th1 Cells / Anti-Inflammatory Agents Type of study: Controlled clinical trial Limits: Adult / Female / Humans / Male Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2020 Type: Article Affiliation country: China Institution/Affiliation country: Nanjing Medical University/CN / Nanjing University of Chinese Medicine/CN

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Full text: Available Index: LILACS (Americas) Main subject: Dexamethasone / Graves Disease / Th2 Cells / Th1 Cells / Anti-Inflammatory Agents Type of study: Controlled clinical trial Limits: Adult / Female / Humans / Male Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2020 Type: Article Affiliation country: China Institution/Affiliation country: Nanjing Medical University/CN / Nanjing University of Chinese Medicine/CN