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Quercetina Melhora o Perfil Lipídico e Apolipoproteico em Ratos Tratados com Glicocorticóides em Altas Doses / Quercetin Ameliorates Lipid and Apolipoprotein Profile in High-Dose Glucocorticoid Treated Rats
Derakhshanian, Hoda; Djalali, Mahmoud; Djazayery, Abolghassem; Javanbakht, Mohammad Hassan; Zarei, Mahnaz; Hekmatdoost, Azita; Eslamian, Ghazaleh; Mirhashemi, Seyyedeh Somayyeh; Dehpour, Ahmad Reza.
  • Derakhshanian, Hoda; Alborz University of Medical Sciences. Probiotic Research Center. Karaj. IR
  • Djalali, Mahmoud; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Djazayery, Abolghassem; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Community Nutrition. Tehran. IR
  • Javanbakht, Mohammad Hassan; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Zarei, Mahnaz; Tehran University of Medical Sciences. School of Nutritional Sciences and Dietetics. Department of Cellular and Molecular Nutrition. Tehran. IR
  • Hekmatdoost, Azita; Shahid Beheshti University of Medical Sciences. Faculty of Nutrition Sciences and Food Technology. National Nutrition and Food Technology Research Institute. Tehran. IR
  • Eslamian, Ghazaleh; Shahid Beheshti University of Medical Sciences. Student Research Committee. Tehran. IR
  • Mirhashemi, Seyyedeh Somayyeh; Alborz University of Medical Sciences. Probiotic Research Center. Karaj. IR
  • Dehpour, Ahmad Reza; Tehran University of Medical Sciences. School of Medicine. Department of Pharmacology. Tehran. IR
Arq. bras. cardiol ; 115(1): 102-108, jul. 2020. tab, graf
Article in English, Portuguese | LILACS, SES-SP | ID: biblio-1131269
RESUMO
Resumo Fundamento Os glicocorticóides (GCs) são amplamente prescritos para o tratamento de numerosos distúrbios clínicos devido às suas propriedades anti-inflamatórias e imunomoduladoras, e um dos efeitos indesejáveis mais comuns desses medicamentos é a dislipidemia. Objetivo Avaliar o efeito da quercetina, um flavonoide derivado de plantas, no perfil lipídico de ratos tratados com glicocorticóides em altas doses. Métodos Um total de 32 ratos Sprague-Dawley foram distribuídos aleatoriamente entre quatro grupos (8 ratos por grupo) e tratados por 6 semanas com uma das seguintes opções (i) solução salina normal; (ii) 40 mg/kg de succinato sódico de metilprednisolona (MP); (iii) MP + 50 mg/kg de quercetina; (iv) MP + 150 mg/kg de quercetina. O MP foi injetado por via subcutânea e a quercetina foi administrada por gavagem oral 3 dias por semana. No final do estudo, o perfil lipídico dos animais foi medido através de kits enzimáticos. Os dados foram analisados e a significância estatística foi estabelecida em p <0,05. Resultados Os níveis séricos médios de colesterol total (CT), triglicerídeos (TG) e LDL aumentaram drasticamente em animais tratados com GC em comparação com o grupo controle. Ambas as doses de quercetina (50 e 150 mg/kg) melhoraram o CT (43% e 45%), LDL (56% e 56%) e TG (46% e 55%, respectivamente). A razão Apo B/A1 diminuiu mais de 20% após a ingestão de Anti-Inflamatory Agents. Conclusões Esses dados sugerem que a ingestão de quercetina Quercetin; induzida por glicocorticóides. (Arq Bras Cardiol. 2020; 115(1)102-108)
ABSTRACT
Abstract Background Glucocorticoids (GCs) are widely prescribed for the treatment of numerous clinical disorders due to their anti-inflammatory and immune-modulatory properties and one of the most common untoward effects of these drugs is dyslipidemia. Objective To evaluate the effect of quercetin, a plant-derived flavonoid, on the lipid profile of high-dose glucocorticoid treated rats. Methods A total of 32 Sprague-Dawley rats, were randomly distributed among four groups (8 rats per group) and treated for 6 weeks with one of the following (i) normal saline; (ii) 40 mg/kg methylprednisolone sodium succinate (MP); (iii) MP + 50 mg/kg quercetin; (iv) MP + 150 mg/kg quercetin. MP was injected subcutaneously, and quercetin was administered by oral gavage 3 days a week. At the end of the study, the animals' lipid profile was measured by enzymatic kits. Data were analyzed and statistical significance was set at p<0.05. Results The mean serum total cholesterol (TC), triglyceride (TG) and LDL levels were drastically increased in GC-treated animals compared with the control group. Both doses of quercetin (50 and 150 mg/kg) ameliorated TC (43% and 45%), LDL (56% and 56%) and TG (46% and 55% respectively). Apo B/A1 ratio decreased more than 20% following quercetin intake and the decline in TC/HDL, TG/HL, LDL/HDL ratios were significant. Conclusions These data suggest that quercetin intake with both doses of 50 and 150 mg/kg could be considered as a protective agent for glucocorticoid-induced dyslipidemia. (Arq Bras Cardiol. 2020; 115(1)102-108.)
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Quercetin / Glucocorticoids Limits: Animals Language: English / Portuguese Journal: Arq. bras. cardiol Year: 2020 Type: Article Institution/Affiliation country: Alborz University of Medical Sciences/IR / Shahid Beheshti University of Medical Sciences/IR / Tehran University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Quercetin / Glucocorticoids Limits: Animals Language: English / Portuguese Journal: Arq. bras. cardiol Year: 2020 Type: Article Institution/Affiliation country: Alborz University of Medical Sciences/IR / Shahid Beheshti University of Medical Sciences/IR / Tehran University of Medical Sciences/IR