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Elastosis Perforans Serpiginosa: a D-penicillamine induced dermatoses in a patient with Wilson's disease
Samal, Swagatika; Sable, Mukund.
  • Samal, Swagatika; All India Institute of Medical Sciences. Department of Pathology. Bhubaneswar. Orissa. IN
  • Sable, Mukund; All India Institute of Medical Sciences. Department of Pathology. Bhubaneswar. Orissa. IN
Autops. Case Rep ; 10(2): e2020167, Apr.-June 2020. graf
Article in English | LILACS | ID: biblio-1131810
ABSTRACT
Long term use of D-penicillamine for Wilson's disease can be associated with many adverse reactions and systemic side effects. We report the case of a 28-year-old male patient diagnosed with Wilson's disease presenting with a serpiginous raised violaceous skin lesion in the anterior aspect of the neck over the last six months and two small papules with central umbilication during the last month. Histopathological examination of skin lesions demonstrated transepidermal perforating channel, and the Verhoeff's-van Gieson stain showed marked increase number of irregular serrated elastic fibers suggesting the diagnosis of D- penicillamine induced elastosis perforans serpiginosa.
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Full text: Available Index: LILACS (Americas) Main subject: Penicillamine / Skin Diseases / Elastic Tissue Limits: Adult / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2020 Type: Article Affiliation country: India Institution/Affiliation country: All India Institute of Medical Sciences/IN

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Full text: Available Index: LILACS (Americas) Main subject: Penicillamine / Skin Diseases / Elastic Tissue Limits: Adult / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2020 Type: Article Affiliation country: India Institution/Affiliation country: All India Institute of Medical Sciences/IN