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Pediatric multifocal histiocytic sarcoma- a fatal diagnosis not to miss!
Shangpliang, Darilin; Baishya, Pakesh; Raphael, Vandana; Dey, Biswajit; Jagtap, Vikas Kantilal.
  • Shangpliang, Darilin; North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences. Department of Pathology. Shillong. IN
  • Baishya, Pakesh; North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences. Department of Pathology. Shillong. IN
  • Raphael, Vandana; North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences. Department of Pathology. Shillong. IN
  • Dey, Biswajit; North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences. Department of Pathology. Shillong. IN
  • Jagtap, Vikas Kantilal; North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences. Department of Radiotherapy and Oncology. Shillong. IN
Autops. Case Rep ; 10(2): e2020170, Apr.-June 2020. tab, graf
Article in English | LILACS | ID: biblio-1131812
ABSTRACT
Histiocytic sarcoma (HS) is a rare hematolymphoid malignant neoplasm with an aggressive clinical course. It can arise de novo or from low-grade B-cell lymphoma. We describe the case of a 16-year-old boy referred to our hospital with generalized lymphadenopathy, weight loss, and decreased appetite for one month. The patient died undiagnosed on the 7th day of hospitalization. Lymph node and bone marrow biopsies were performed one day before the patient died. The lymph node biopsy revealed an architectural effacement with a diffuse proliferation of large pleomorphic neoplastic cells containing large, multilobulated nuclei, coarse vesicular chromatin, prominent nucleoli, and a moderate amount of eosinophilic cytoplasm. The bone marrow aspiration smears and biopsy also showed evidence of infiltration by these above-mentioned cells. Based on the morphology, along with the exclusion of many differential diagnoses by an extensive panel of immunohistochemical markers, a diagnosis of HS was made. This case report aims at evaluating all the clinical and immunophenotypic features of a case of HS with multifocal presentation and an aggressive clinical course in order to give a correct and definite diagnosis at the proper time.
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Full text: Available Index: LILACS (Americas) Main subject: Histiocytic Sarcoma Type of study: Diagnostic study Limits: Adolescent / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2020 Type: Article Affiliation country: India Institution/Affiliation country: North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences/IN

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Full text: Available Index: LILACS (Americas) Main subject: Histiocytic Sarcoma Type of study: Diagnostic study Limits: Adolescent / Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2020 Type: Article Affiliation country: India Institution/Affiliation country: North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences/IN