Two cases of rare HHV8-driven intravascular lymphoma with synchronous Kaposi sarcoma, both diagnosed at autopsy in renal transplant recipients
Autops. Case Rep
;
10(4): e2020206, 2020. graf
Article
in English
| LILACS
| ID: biblio-1131860
ABSTRACT
We present the first report of two rare yet remarkably similar autopsy cases of Kaposi sarcoma (KS) and intravascular human herpesvirus 8 (HHV8) positive lymphoproliferative disorder in renal transplant patients. It is well established that HHV8 infection causes Kaposi sarcoma (KS). More recently, it is recognized that HHV8 is also related to several lymphoproliferative conditions. These are poorly characterized and often difficult to diagnose. In both cases described herein, the diagnoses of multifocal hepatic KS and intravascular HHV8 positive (EBV negative) systemic diffuse large B-cell lymphoma, NOS were made at autopsy. Given the findings we describe in cases with fatal outcomes, we discuss the implications of HHV8 screening in solid allograft recipients.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Sarcoma, Kaposi
/
Herpesvirus 8, Human
/
Lymphoproliferative Disorders
Type of study:
Diagnostic study
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Autops. Case Rep
Journal subject:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Year:
2020
Type:
Article
Affiliation country:
United kingdom
Institution/Affiliation country:
North Bristol NHS Trust/GB
/
Peterborough City Hospital/GB
/
Royal Liverpool University Hospital/GB
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