The roles of miRNA, lncRNA and circRNA in the development of osteoporosis
Biol. Res
;
53: 40, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1131891
ABSTRACT
Osteoporosis is a common metabolic bone disease, influenced by genetic and environmental factors, that increases bone fragility and fracture risk and, therefore, has a serious adverse effect on the quality of life of patients. However, epigenetic mechanisms involved in the development of osteoporosis remain unclear. There is accumulating evidence that epigenetic modifications may represent mechanisms underlying the links of genetic and environmental factors with increased risk of osteoporosis and bone fracture. Some RNAs, such as microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), have been shown to be epigenetic regulators with significant involvement in the control of gene expression, affecting multiple biological processes, including bone metabolism. This review summarizes the results of recent studies on the mechanisms of miRNA-, lncRNA-, and circRNA-mediated osteoporosis associated with osteoblasts and osteoclasts. Deeper insights into the roles of these three classes of RNA in osteoporosis could provide unique opportunities for developing novel diagnostic and therapeutic approaches to this disease.
Full text:
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Index:
LILACS (Americas)
Main subject:
Osteoporosis
/
MicroRNAs
/
RNA, Long Noncoding
/
RNA, Circular
Limits:
Humans
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2020
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Peoples Hospital of Guazhou County/CN
/
Second Clinical Medical College of Lanzhou University/CN
/
Sichuan University/CN
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