Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans
Braz. J. Pharm. Sci. (Online)
;
56: e18599, 2020. tab
Article
in English
| LILACS
| ID: biblio-1132042
ABSTRACT
The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions were evaluated using checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Fluconazole
/
Ibuprofen
/
Itraconazole
/
Cryptococcus neoformans
Type of study:
Practice guideline
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Rio Grande do Sul/BR
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