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Targeting of temozolomide using magnetic nanobeads: an in vitro study
Gürten, Berna; Yenigül, Elçin; Sezer, Ali Demir; Altan, Cem; Malta, Seyda.
  • Gürten, Berna; Yeditepe University. Faculty of Engineering. Department of Chemical Engineering. Ataşehir. TR
  • Yenigül, Elçin; Yeditepe University. Faculty of Engineering. Department of Chemical Engineering. Ataşehir. TR
  • Sezer, Ali Demir; Marmara University. Faculty of Pharmacy. Department of Pharmaceutical Biotechnology. Haydarpaşa. TR
  • Altan, Cem; Yeditepe University. Faculty of Engineering. Department of Chemical Engineering. Ataşehir. TR
  • Malta, Seyda; Yeditepe University. Faculty of Engineering. Department of Chemical Engineering. Ataşehir. TR
Braz. J. Pharm. Sci. (Online) ; 56: e18579, 2020. tab, graf
Article in English | LILACS | ID: biblio-1132059
ABSTRACT
Temozolomide, a chemotherapeutic drug that is often administered for the treatment of brain cancer has severe side effects and a poor aqueous solubility. In order to decrease the detrimental effect of the drug over healthy cells, a novel drug delivery vehicle was developed where the therapeutic drug was encapsulated within the hydrophobic cavities of b-CD modified magnetite nanoparticles, which are embedded in chitosan nanobeads prepared by salt addition. In-vitro studies have shown that the magnetic properties of the novel delivery vehicle are adequate for targeted drug delivery applications under an external magnetic field. Additionally, an increase in the amount of chitosan was shown to exhibit a strong shielding effect over the magnetic properties of the delivery vehicle, which lead to deterioration of the amount of captured drug at the targeted area, suggesting a delicate balance between the amounts of constituents composing the drug delivery vehicle.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: In Vitro Techniques / Brain Neoplasms / Temozolomide Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Marmara University/TR / Yeditepe University/TR

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Full text: Available Index: LILACS (Americas) Main subject: In Vitro Techniques / Brain Neoplasms / Temozolomide Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Marmara University/TR / Yeditepe University/TR