Adjunctive vortioxetine for SSRI-resistant major depressive disorder: a real-world chart review study
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
42(3): 317-321, May-June 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1132080
ABSTRACT
Objective:
Selective serotonin reuptake inhibitors (SSRIs) are the cornerstone of treatment of major depressive disorder (MDD). However, non-response is common, often necessitating combination strategies. The present study assessed the efficacy of vortioxetine as an add-on therapy in patients with SSRI-resistant MDD.Methods:
The charts of 36 adult outpatients with DSM-IV-TR MDD who had not achieved a response after at least 8 weeks of treatment with an SSRI were reviewed retrospectively. Subjects were treated with vortioxetine (5-20 mg/day) for 8 weeks added to the current SSRI. The main outcome measures were change from baseline in total Hamilton Scale for Depression (HAM-D) score and the rate of response (a 50% or greater reduction in HAM-D score and a Clinical Global Impression ‐ Improvement module [CGI-I] score of 1 or 2 at endpoint). HAM-D scores ≤ 7 were considered as remission. Additional outcome measures included the Snaith-Hamilton Pleasure Scale (SHAPS) and the Scale for Suicide Ideation (SSI).Results:
32 patients completed the 8 weeks of treatment. At 8 weeks, a significant reduction in HAM-D score was observed (p ≤ 0.001), with response obtained by 41.7% and remission by 33.3% of patients. Significant reductions in SHAPS and SSI were also observed (p ≤ 0.001 for both scales).Conclusions:
Adjunctive vortioxetine may be useful and well-tolerated in stage I treatment-resistant depression. However, the limitations of this study (such as small sample size, absence of randomization and control group, retrospective design, etc.) must be considered.
Full text:
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Index:
LILACS (Americas)
Main subject:
Depressive Disorder, Major
/
Depressive Disorder, Treatment-Resistant
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Serotonin and Noradrenaline Reuptake Inhibitors
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Vortioxetine
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Antidepressive Agents
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2020
Type:
Article
Affiliation country:
Italy
Institution/Affiliation country:
Federico II University/IT
/
Hermanas Hospitalarias, Villa San Benedetto Menni Hospital, FoRiPsi/IT
/
Hospital G. Mazzini, National Health Service (NHS)/IT
/
Hospital Madonna Del Soccorso NHS/IT
/
Hospital SS. Annunziata NHS/IT
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Hospital San Camillo de Lellis NHS/IT
/
Polyedra/IT
/
S. Andrea Hospital, Sapienza University/IT
/
University G. DAnnunzio Chieti/IT
/
University of Foggia/IT
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