Early diagnosis and treatment of Alzheimers disease: new definitions and challenges
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
42(4): 431-441, July-Aug. 2020. tab
Article
in English
| LILACS
| ID: biblio-1132093
ABSTRACT
The prevalence of Alzheimer's disease (AD), a progressive neurodegenerative disorder, is expected to more than double by 2050. Studies on the pathophysiology of AD have been changing our understanding of this disorder and setting a new scenario for drug development and other therapies. Concepts like the "amyloid cascade" and the "continuum of AD," discussed in this article, are now well established. From updated classifications and recommendations to advances in biomarkers of AD, we aim to critically assess the literature on AD, addressing new definitions and challenges that emerged from recent studies on the subject. Updates on the status of major clinical trials are also given, and future perspectives are discussed.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Brain
/
Early Diagnosis
/
Alzheimer Disease
Type of study:
Diagnostic study
/
Practice guideline
/
Risk factors
/
Screening study
Limits:
Humans
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Departamento e Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HCFMUSP)/BR
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