Health-related quality of life in patients treated with atypical antipsychotics
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
42(6): 599-607, Nov.-Dec. 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1132149
ABSTRACT
Objective:
To assess health-related quality of life and associated factors in patients treated with atypical antipsychotics, as well as to determine utility values using the EuroQol-5D-3L instrument.Methods:
A cross-sectional study was conducted at a state-run pharmacy in the Brazilian National Health System. Individuals were included if they were using a single atypical antipsychotic and completed the EuroQol-5D-3L. Sociodemographic, behavioral, and clinical data were collected. The dependent variable was the EuroQol-5D-3L utility score. Associations between the independent variables and the dependent variable were analyzed in a multiple linear regression model.Results:
A total of 394 patients were included, and their mean utility score was 0.664±0.232. Patients treated with clozapine had the highest mean score (0.762 [0.202]), followed by olanzapine (0.687 [0.230]), risperidone (0.630 [0.252]), ziprasidone (0.622 [0.234]), and quetiapine (0.620 [0.243]). The following variables were related to higher utility scores income, employment, clozapine use, no illicit psychoactive substance use, no suicide attempts, and no comorbidities.Conclusion:
Evaluating health-related quality of life differences in the available atypical antipsychotics can facilitate the choice of treatment, improve health outcomes, and ensure rational prescriptions.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Schizophrenia
/
Antipsychotic Agents
Type of study:
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2020
Type:
Article
Affiliation country:
Brazil
/
Canada
Institution/Affiliation country:
UFMG/BR
/
Universidade Federal de Minas Gerais (UFMG)/BR
/
University of Toronto/CA
Similar
MEDLINE
...
LILACS
LIS