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Effect of Cilostazol-Loaded PCL/PEG Nanocapsules on Abdominal Aortic Tunics and Lipid Profile of Wistar Rats
Pilatti, Luís Daniel Silva; Rodrigues, Ricardo; Nascimento, Núbia da Silva; Gomes, Mona Lisa Simionatto; Zanin, Sandra Maria Warumby; Farago, Paulo Vitor; Busato, César Roberto.
  • Pilatti, Luís Daniel Silva; State University of Ponta Grossa. Department of Medicine. Ponta Grossa. BR
  • Rodrigues, Ricardo; State University of Ponta Grossa. Department of Medicine. Ponta Grossa. BR
  • Nascimento, Núbia da Silva; State University of Ponta Grossa. Department of Medicine. Ponta Grossa. BR
  • Gomes, Mona Lisa Simionatto; State University of Ponta Grossa. Department of Pharmaceutical Sciences. Ponta Grossa. BR
  • Zanin, Sandra Maria Warumby; Federal University of Paraná. Department of Pharmacy. Curitiba. BR
  • Farago, Paulo Vitor; State University of Ponta Grossa. Department of Pharmaceutical Sciences. Ponta Grossa. BR
  • Busato, César Roberto; State University of Ponta Grossa. Department of Medicine. Ponta Grossa. BR
Braz. arch. biol. technol ; 63: e20200062, 2020. tab, graf
Article in English | LILACS | ID: biblio-1132243
ABSTRACT
Abstract Cilostazol (CLZ) is a phosphodiesterase III inhibitor with antiplatelet and vasodilator properties. It has been recently verified that CLZ plays a significant role in the arteries by inhibiting the proliferation and growth of muscle cells, increasing the release of nitric oxide by the endothelium and promoting angiogenesis. Considering these promising effects, the use of nanocapsules may be an interesting strategy to optimize its pharmacokinetics and pharmacodynamics at the vascular level for preventing atherosclerosis. The aim of this study was to evaluate the effect of cilostazol-loaded nanocapsules in the abdominal aortic tunics and on the lipid profile of Wistar rats in order to investigate its potential role in the prevention of atherosclerosis. Thirty-two animals were divided into four groups of eight animals, with 30-day treatment. Group 1 received nanoencapsulated CLZ; Group 2, control nanocapsules with no drug; Group 3, propylene glycol and water; and Group 4, a solution of CLZ in propylene glycol and water. After 30 days, there was no statistically significant difference between the groups regarding the cellularity and thickness of the arterial tunics of the abdominal aorta. However, the group that received nanoencapsulated CLZ (Group 1) had an improvement in HDL-c and triglyceride values compared to unloaded nanocapsules (Group 2).
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Full text: Available Index: LILACS (Americas) Main subject: Vasodilator Agents / Platelet Aggregation Inhibitors / Nanocapsules / Phosphodiesterase 3 Inhibitors / Cilostazol Limits: Animals Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraná/BR / State University of Ponta Grossa/BR

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Full text: Available Index: LILACS (Americas) Main subject: Vasodilator Agents / Platelet Aggregation Inhibitors / Nanocapsules / Phosphodiesterase 3 Inhibitors / Cilostazol Limits: Animals Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraná/BR / State University of Ponta Grossa/BR