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Upper Zone of Growth Plate and Cartilage Matrix (UCMA) Levels in Patients with Chronic Kidney Disease
Okuyan, Hamza Malik; Özcan, Oğuzhan; Doğan, Serdar; Arpacı, Abdullah; Turgut, Faruk Hilmi.
  • Okuyan, Hamza Malik; Sakarya University of Applied Sciences. Faculty of Health Sciences. Department of Physiotherapy and Rehabilitation. Sakarya. TR
  • Özcan, Oğuzhan; Hatay Mustafa Kemal University. Faculty of Medicine. Department of Biochemistry. Hatay. TR
  • Doğan, Serdar; Hatay Mustafa Kemal University. Faculty of Medicine. Department of Biochemistry. Hatay. TR
  • Arpacı, Abdullah; Hatay Mustafa Kemal University. Faculty of Medicine. Department of Biochemistry. Hatay. TR
  • Turgut, Faruk Hilmi; Hatay Mustafa Kemal University. Faculty of Medicine. Department of Nephrology. Hatay. TR
Braz. arch. biol. technol ; 63: e20190594, 2020. tab, graf
Article in English | LILACS | ID: biblio-1132264
ABSTRACT
Abstract Chronic kidney disease (CKD) is an important health problem across the world affecting the adult population with an enormous social and economic burden. Calcium regulation is also affected in patients with CKD, and related to several disorders including vascular calcifications, mineral bone disorders, and cardiovascular diseases (CVD). Upper zone of growth plate and cartilage matrix (UCMA) is vitamin K-dependent protein (VKDP) and acts as a calcification inhibitor in the cardiovascular system. The molecular mechanism of UCMA action remains unclear in CKD. In the current study, we aimed to investigate serum total UCMA levels and its association with calcium metabolism parameters in CKD patients including hemodialysis (HD) patients. Thirty-seven patients with CKD stage 3-5, 41 HD patients, and 34 healthy individuals were enrolled in this cross-sectional study. Serum UCMA and calcification related protein levels (Matrix Gla Protein (MGP), Osteocalcin (OC), and Fetuin-A) were analyzed with enzyme-linked immunosorbent assay (ELISA). Calcium mineral disorder parameters (Serum Ca, P, iPTH) were quantified with routine techniques. We, for the first time, report the potential biomarker role of UCMA in CKD including HD. Serum total UCMA levels were significantly higher in patients with CKD including HD patients than the healthy controls. Also, serum UCMA levels showed negative correlations with serum calcium, and eGFR, while showed positive relationships with P, iPTH, MGP, OC. Increased total UCMA levels may have a role in the Ca metabolism disorder and related to the pathogenesis of Vascular Calcification in patients with CKD.
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Full text: Available Index: LILACS (Americas) Main subject: Osteocalcin / Calcium / Renal Insufficiency, Chronic / Matrilin Proteins / Growth Plate Type of study: Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Hatay Mustafa Kemal University/TR / Sakarya University of Applied Sciences/TR

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Full text: Available Index: LILACS (Americas) Main subject: Osteocalcin / Calcium / Renal Insufficiency, Chronic / Matrilin Proteins / Growth Plate Type of study: Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Hatay Mustafa Kemal University/TR / Sakarya University of Applied Sciences/TR