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Development and Characterization of Poly-ε -caprolactone Nanocapsules Containing β -carotene Using the Nanoprecipitation Method and Optimized by Response Surface Methodology
Lino, Renata Calegari; Carvalho, Sabrina Matos de; Noronha, Carolina Montanheiro; Sganzerla, William Gustavo; Rosa, Cleonice Gonçalves da; Nunes, Michael Ramos; Barreto, Pedro Luiz Manique.
  • Lino, Renata Calegari; Federal University of Santa Catarina. Post-Graduate Program in Food Science. Florianopolis. BR
  • Carvalho, Sabrina Matos de; Federal University of Santa Catarina. Post-Graduate Program in Food Science. Florianopolis. BR
  • Noronha, Carolina Montanheiro; Federal University of Santa Catarina. Post-Graduate Program in Food Science. Florianopolis. BR
  • Sganzerla, William Gustavo; University of Campinas. School of Food Engineering. Post-Graduate Program in Food Engineering. Campinas. BR
  • Rosa, Cleonice Gonçalves da; Federal University of Santa Catarina. Post-Graduate Program in Food Science. Florianopolis. BR
  • Nunes, Michael Ramos; Federal Institute of Santa Catarina. Lages. BR
  • Barreto, Pedro Luiz Manique; Federal University of Santa Catarina. Post-Graduate Program in Food Science. Florianopolis. BR
Braz. arch. biol. technol ; 63: e20190184, 2020. tab, graf
Article in English | LILACS | ID: biblio-1132268
ABSTRACT
Abstract Nanoparticles demonstrate an important role in the protection of bioactive compounds from external factors such as temperature, oxygen and light. In this study, poly-ε-caprolactone (PCL) nanoparticles entrapped β-carotene was produced using the nanoprecipitation method. Firstly, was evaluated the lipophilic surfactant effect and carrier agent of the active compound in the nanocapsules formulation. After choosing the most stable formulation, the nanocapsules production was optimized using β-carotene, caprylic/capric triglycerides (CCT) and soybean lecithin. Response surface methodology (RSM) was adopted to evaluate the influence of soy lecithin concentration, volume of CCT and β-carotene concentration in the particle size, zeta potential, polydispersity index (PDI), encapsulation efficiency and recovery. Formulations containing soy lecithin and CCT demonstrated better stability comparing to the other formulations tested. The nanoparticle formulations presented an optimized particle size below 200 nm, PDI lower than 0.1 and encapsulation efficiency above 95%. Based on the results obtained, the optimum conditions to prepare PCL nanocapsules were 0.2160 mg/mL of β-carotene, 232.42 μL of CCT and 2.59 mg/mL of soy lecithin, suggesting an applicability to promote controlled released of β-carotene in food system.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Caproates / Beta Carotene / Nanotechnology / Nanocapsules / Lactones Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal Institute of Santa Catarina/BR / Federal University of Santa Catarina/BR / University of Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Caproates / Beta Carotene / Nanotechnology / Nanocapsules / Lactones Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal Institute of Santa Catarina/BR / Federal University of Santa Catarina/BR / University of Campinas/BR