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Serum levels of matrix metalloproteinase-2, -9, and vitamin D in patients with multiple sclerosis with or without herpesvirus-6 seropositivity
Amini, Razieh; karampoor, Sajad; Zahednasab, Hamid; Keyvani, Hossein; Gheiasian, Masoud; Jalilian, Farid Azizi.
  • Amini, Razieh; Hamadan University of Medical Sciences. Faculty of Medicine. Department of Molecular Medicine and Genetics. Hamadan. IR
  • karampoor, Sajad; Iran University of Medical Sciences. School of Medicine. Department of Virology. Tehran. IR
  • Zahednasab, Hamid; University of Tehran. Institute of Biochemistry and Biophysics. Tehran. IR
  • Keyvani, Hossein; Iran University of Medical Sciences. School of Medicine. Department of Virology. Tehran. IR
  • Gheiasian, Masoud; Hamadan University of Medical Sciences. Faculty of Medicine. Department of Neurology. Hamadan. IR
  • Jalilian, Farid Azizi; Hamadan University of Medical Sciences. Faculty of Medicine Hamadan. Department of Medical Virology. Hamadan. IR
Braz. j. infect. dis ; 24(2): 144-149, Mar.-Apr. 2020. tab, graf
Article in English | LILACS, ColecionaSUS | ID: biblio-1132435
ABSTRACT
ABSTRACT In recent years, extreme attention has been focused on the role of human herpesvirus-6 (HHV-6) in multiple sclerosis (MS) pathogenesis. However, the pathogenesis of MS associated with HHV-6 infection remains unknown. In this study, we measured the serum levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection. Five hundred sixty (including 300 females and 260 males) MS patients along with 560 healthy subjects were analyzed for HHV-6 seropositivity using enzyme-linked immunosorbent assay (ELISA). Subsequently, we measured the serum levels of MMP-2, MMP-9, and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection by ELISA. About 90.7% of MS patients (508/560) were seropositive for HHV-6, while 82.3% (461/560) of healthy subjects were seropositive for this virus (p = 0.001). Moreover, there was a significant increase in the levels of MMP-2, MMP-9, and lower vitamin D in the serum samples of MS patients when compared with healthy subjects. Additionally, we demonstrated that the MMP-9 levels in seropositive MS patients were significantly higher than seronegative MS patients (p = 0.001). Finally, our results demonstrated that the mean of expanded disability status scale (EDSS) in seropositive MS patients was significantly higher in comparison to seronegative MS patients (p < 0.05). In conclusion, we suggest that the HHV-6 infection may play a role in MS pathogenesis.
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Full text: Available Index: LILACS (Americas) Main subject: Vitamin D / Roseolovirus Infections / Matrix Metalloproteinase 2 / Matrix Metalloproteinase 9 / Multiple Sclerosis Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Year: 2020 Type: Article Institution/Affiliation country: Hamadan University of Medical Sciences/IR / Iran University of Medical Sciences/IR / University of Tehran/IR

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Full text: Available Index: LILACS (Americas) Main subject: Vitamin D / Roseolovirus Infections / Matrix Metalloproteinase 2 / Matrix Metalloproteinase 9 / Multiple Sclerosis Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Year: 2020 Type: Article Institution/Affiliation country: Hamadan University of Medical Sciences/IR / Iran University of Medical Sciences/IR / University of Tehran/IR