Viral metagenomics performed in patients with acute febrile syndrome during Toxoplasma gondii outbreak in south Brazil
Braz. j. infect. dis
;
24(3): 250-255, May-June 2020. graf
Article
in English
|
LILACS-Express
| LILACS, ColecionaSUS
| ID: biblio-1132440
ABSTRACT
ABSTRACT Toxoplasmosis is a zoonotic infection caused by the protozoan parasite Toxoplasma gondii. The infection is widely disseminated in the human population and is usually benign or asymptomatic. Systemic T. gondii infection presents risks for pregnant women and AIDS patients. Although rare, T. gondii can cause outbreaks in urban centers. The origin of these outbreaks is not completely understood but probably results from introduction of zoonotic T. gondii strains in the population. During such outbreaks other pathogens which mimic T. gondii acute febrile syndrome may also circulate; therefore, detailed investigation of the outbreak is of extreme importance. In this study we performed viral metagenomics next-generation sequencing (mNGS) in patient samples obtained during T. gondii outbreak in Santa Maria city, South Brazil. Specific bioinformatics pipelines specialized in virus discovery were applied in order to identify co-circulating vial agents. Epstein Barr virus and Parvovirus B19 contigs were assembled and these viruses can cause symptoms similar to toxoplasmosis. In conclusion, our findings show the importance of Metagenomics next generation sequencing (mNGS) use to help characterize the outbreak more completely and in the management of the affected patients.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Prognostic study
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. infect. dis
Year:
2020
Type:
Article
/
Project document
Institution/Affiliation country:
Hospital De Caridade Dr. Astrogildo De Azevedo/BR
/
Universidade de São Paulo/BR
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