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Effects of the prophylactic use of escitalopram on the prognosis and the plasma copeptin level in patients with acute cerebral infarction
Cao, Jin-Xia; Liu, Li; Sun, Yun-Tao; Zeng, Qing-Hong; Wang, Yan; Chen, Jie-Chun.
  • Cao, Jin-Xia; Second Peoples Hospital of Lianyungang. Department of Neuropsychiatry. Jiangsu. CN
  • Liu, Li; Second Peoples Hospital of Lianyungang. Department of Neuropsychiatry. Jiangsu. CN
  • Sun, Yun-Tao; Second Peoples Hospital of Lianyungang. Department of Neuropsychiatry. Jiangsu. CN
  • Zeng, Qing-Hong; Second Peoples Hospital of Lianyungang. Department of Neurology. Jiangsu. CN
  • Wang, Yan; Second Peoples Hospital of Lianyungang. Department of Laboratory. Jiangsu. CN
  • Chen, Jie-Chun; Second Peoples Hospital of Lianyungang. Department of Neurology. Jiangsu. CN
Braz. j. med. biol. res ; 53(11): e8930, 2020. tab
Article in English | LILACS, ColecionaSUS | ID: biblio-1132486
ABSTRACT
This study aimed to investigate whether the routine administration of escitalopram for three months would improve the prognosis of patients with ischemic stroke and decrease the plasma copeptin level. A total of 97 patients with acute cerebral infarction were randomly allocated to receive escitalopram (5-10 mg once per day, orally; n=49) or not to receive escitalopram (control group; n=48) for 12 weeks starting at 2-7 days after the onset of stroke. Both groups received conventional treatments, including physiotherapy and secondary prevention of stroke. The National Institutes of Health Stroke Scale (NIHSS) score was used to evaluate the disability of patients at the initial evaluation and at the monthly follow-up visits for three months. Impairment in the daily activities was assessed using the Barthel Index (BI), while cognitive impairment was assessed using Mini-Mental State Examination (MMSE) score. The psychiatric assessment included the administration of the Present State Examination modified to identify Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) symptoms of depression. The severity of depression was measured using the 17-item Hamilton Rating Scale for Depression (HAMD). During the 3-month follow-up period, 95 patients were included in the analysis (two patients withdrew from the escitalopram group). NIHSS and BI improvement at the 90th day were significantly greater in the escitalopram group (P<0.05), while HAMD and plasma copeptin levels significantly decreased, compared to the control group (P<0.01). In patients with acute ischemic stroke, the earlier administration of escitalopram for three months may improve neurological functional prognosis and decrease copeptin level.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Cerebral Infarction / Brain Ischemia / Stroke Type of study: Controlled clinical trial / Practice guideline / Prognostic study Limits: Humans Country/Region as subject: North America Language: English Journal: Braz. j. med. biol. res Year: 2020 Type: Article Institution/Affiliation country: Second Peoples Hospital of Lianyungang/CN

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Full text: Available Index: LILACS (Americas) Main subject: Cerebral Infarction / Brain Ischemia / Stroke Type of study: Controlled clinical trial / Practice guideline / Prognostic study Limits: Humans Country/Region as subject: North America Language: English Journal: Braz. j. med. biol. res Year: 2020 Type: Article Institution/Affiliation country: Second Peoples Hospital of Lianyungang/CN