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Association of circulating long non-coding RNA MALAT1 in diagnosis, disease surveillance, and prognosis of acute ischemic stroke
Ren, Hongbo; Wu, Feng; Liu, Bin; Song, Zhiyuan; Qu, Dacheng.
Affiliation
  • Ren, Hongbo; HanDan Central Hospital. Department of Neurosurgery. CN
  • Wu, Feng; HanDan Central Hospital. Department of Neurosurgery. CN
  • Liu, Bin; HanDan Central Hospital. Department of Neurosurgery. CN
  • Song, Zhiyuan; HanDan Central Hospital. Department of Neurosurgery. CN
  • Qu, Dacheng; Hebei University of Engineering. Department of Neurosurgery. CN
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;53(12): e9174, 2020. tab, graf
Article in En | LILACS, ColecionaSUS | ID: biblio-1132510
Responsible library: BR1.1
ABSTRACT
We aimed to investigate the association of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (lnc-MALAT1) with acute ischemic stroke (AIS), and its association with disease severity, inflammation, and recurrence-free survival (RFS) in AIS patients. One hundred and twenty AIS patients and 120 controls were recruited. Venous blood samples from AIS patients (within 24 h after symptoms onset) and controls (at entry to study) were collected to detect plasma lnc-MALAT1 expression by real-time quantitative polymerase chain reaction. AIS severity was assessed by the National Institutes of Health Stroke Scale (NIHSS) score. Plasma concentrations of inflammation factors (including C-reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-8, IL-10, IL-17, and IL-22) were measured and RFS was calculated. lnc-MALAT1 expression was decreased in AIS patients compared to controls, and it had a close correlation with AIS (AUC=0.791, 95% CI 0.735-0.846). For disease condition, lnc-MALAT1 expression negatively correlated with NIHSS score and pro-inflammatory factor expression (including CRP, TNF-α, IL-6, IL-8, and IL-22), while it positively correlated with anti-inflammatory factor IL-10 expression. Furthermore, lnc-MALAT1 expression was elevated in AIS patients with diabetes. For prognosis, no statistical correlation of lnc-MALAT1 expression with RFS was found, while a trend for longer RFS was observed in patients with lnc-MALAT1 high expression compared to those with lnc-MALAT1 low expression.
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Full text: 1 Index: LILACS Main subject: Brain Ischemia / Stroke / RNA, Long Noncoding / Ischemic Stroke Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Aged / Female / Humans / Male Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 2020 Type: Article

Full text: 1 Index: LILACS Main subject: Brain Ischemia / Stroke / RNA, Long Noncoding / Ischemic Stroke Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Aged / Female / Humans / Male Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 2020 Type: Article