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High levels of chemerin associated with variants in the NOS3 and APOB genes in rural populations of Ouro Preto, Minas Gerais, Brazil
Batista, A P; Barbosa, K F; Masioli, C Z; Queiroz, E M; Marinho, C C; Cândido, A P C; Machado-Coelho, G L L.
  • Batista, A P; Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisa em Ciências Biológicas. Ouro Preto. BR
  • Barbosa, K F; Universidade Federal de Ouro Preto. Saúde Mental e Coletiva, Escola de Medicina. Laboratório de Epidemiologia. Ouro Preto. BR
  • Masioli, C Z; Universidade Federal de Ouro Preto. Saúde Mental e Coletiva, Escola de Medicina. Laboratório de Epidemiologia. Ouro Preto. BR
  • Queiroz, E M; Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisa em Ciências Biológicas. Ouro Preto. BR
  • Marinho, C C; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte. BR
  • Cândido, A P C; Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Departamento de Nutrição. Juiz de Fora. BR
  • Machado-Coelho, G L L; Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisa em Ciências Biológicas. Ouro Preto. BR
Braz. j. med. biol. res ; 53(6): e9113, 2020. tab, graf
Article in English | LILACS, ColecionaSUS | ID: biblio-1132518
ABSTRACT
Chemerin is an adipokine that has been associated with components of metabolic syndrome. It has been described to affect adipocyte metabolism and inflammatory responses in adipose tissue, as well as the systemic metabolism of lipids and glucose. Few epidemiological studies have evaluated classical and genetics cardiovascular risk factors (CVRFs) in the mixed adult rural population in Brazil. Therefore, the present study explored possible associations between CVRFs and chemerin. This cross-sectional study included 508 adults from the rural localities of Lavras Novas, Chapada, and Santo Antônio do Salto in Ouro Preto, Minas Gerais, Southeast Brazil. Demographic, behavioral, clinical, biochemical, anthropometric variables, and 12 single nucleotide polymorphisms (SNPs) linked with metabolic syndrome phenotypes were evaluated for associations with chemerin level. There was a significant association of high triglyceride levels [odds ratio (OR)=1.91, 95%CI 1.23−2.98], insulin resistance (OR=1.82, 95%CI 1.03−3.22), age (OR=1.64, 95%CI 1.08−2.49), and sex (OR=1.99, 95%CI 1.35−2.95) with high levels of chemerin. High chemerin levels were significantly associated with the genetic polymorphisms rs693 in the APOB gene (OR=1.50, 95%CI 1.03−2.19) and rs1799983 in the NOS3 gene (OR=1.46, 95%CI 1.01−2.12) for the AA and GT+TT genotypes, respectively. In the concomitant presence of genotypes AA of rs693 and GT+TT of rs1799983, the chance of presenting high levels of chemerin showed a 2.21-fold increase (95%CI 1.25−3.88) compared to the reference genotype. The development of classical CVRFs in this population may be influenced by chemerin and by two risk genotypes characteristic of variants in well-studied genes for hypertension and dyslipidemia.
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Full text: Available Index: LILACS (Americas) Main subject: Apolipoproteins B / Cardiovascular Diseases / Chemokines / Polymorphism, Single Nucleotide / Nitric Oxide Synthase Type III Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Year: 2020 Type: Article Institution/Affiliation country: Universidade Federal de Juiz de Fora/BR / Universidade Federal de Minas Gerais/BR / Universidade Federal de Ouro Preto/BR

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Full text: Available Index: LILACS (Americas) Main subject: Apolipoproteins B / Cardiovascular Diseases / Chemokines / Polymorphism, Single Nucleotide / Nitric Oxide Synthase Type III Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Year: 2020 Type: Article Institution/Affiliation country: Universidade Federal de Juiz de Fora/BR / Universidade Federal de Minas Gerais/BR / Universidade Federal de Ouro Preto/BR