Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis
Braz. j. med. biol. res
;
53(7): e9646, 2020. graf
Article
in English
| LILACS, ColecionaSUS
| ID: biblio-1132528
ABSTRACT
Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have symptoms and signs of HF with normal or near-normal left ventricular ejection fraction (LVEF ≥50%). Roughly half of all patients with HF worldwide have an LVEF ≥50% and nearly half have an LVEF <50%. Thanks to the increased scientific attention about the condition and improved characterization and diagnostic tools, the incidence of HF with reduced ejection fraction (HFrEF) dropped while that of HFpEF has increased by 45%. HFpEF has no single guideline for diagnosis or treatment, the patient population is heterogeneously and inconsistently described, and longitudinal studies are lacking. To better understand and overcome the disease, in this review, we updated the latest knowledge of HFpEF pathophysiology, introduced the existing promising diagnostic methods and treatments, and summarized its prognosis by reviewing the most recent cohort studies.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Stroke Volume
/
Ventricular Function, Left
/
Heart Failure
Type of study:
Diagnostic study
/
Practice guideline
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Year:
2020
Type:
Article
Institution/Affiliation country:
Berlin Institute of Health Center for Regenerative Therapies & Berlin - Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum (CVK)/DE
/
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health/DE
/
Henan Provincial Peoples Hospital/CN
/
Second Affiliated Hospital of Zhengzhou University/CN
Similar
MEDLINE
...
LILACS
LIS