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In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma / Estudo in vivo e in vitro da coexpressão de LMP1 e Cripto-1 em carcinoma nasofaríngeo
Ye, Qing; Li, Jing; Wang, Xiaoyan; Zhang, Xianzeng; Lin, Jun; Huo, Yuting; Sun, Zhengzhen; Xie, Shusen; Huang, Zheng.
  • Ye, Qing; Fujian Medical University. Fujian Provincial Hospital and Provincial Clinical College. Department of Otolaryngology. Fujian. CN
  • Li, Jing; Fujian Medical University. Fujian Provincial Hospital and Provincial Clinical College. Department of Otolaryngology. Fujian. CN
  • Wang, Xiaoyan; Fujian Medical University. Fujian Provincial Hospital and Provincial Clinical College. Department of Otolaryngology. Fujian. CN
  • Zhang, Xianzeng; Fujian Normal University. OptoElectronic Science and Technology for Medicine. MOE Key Laboratory. Fujian. CN
  • Lin, Jun; Fujian Medical University. Fujian Provincial Hospital and Provincial Clinical College. Department of Otolaryngology. Fujian. CN
  • Huo, Yuting; Fujian Medical University. Fujian Provincial Hospital and Provincial Clinical College. Department of Otolaryngology. Fujian. CN
  • Sun, Zhengzhen; Fujian Medical University. Fujian Provincial Hospital and Provincial Clinical College. Department of Otolaryngology. Fujian. CN
  • Xie, Shusen; Fujian Normal University. OptoElectronic Science and Technology for Medicine. MOE Key Laboratory. Fujian. CN
  • Huang, Zheng; Fujian Normal University. OptoElectronic Science and Technology for Medicine. MOE Key Laboratory. Fujian. CN
Braz. j. otorhinolaryngol. (Impr.) ; 86(5): 617-625, Sept.-Oct. 2020. tab, graf
Article in English | LILACS | ID: biblio-1132640
ABSTRACT
Abstract

Introduction:

Nasopharyngeal carcinoma, an epithelial-derived malignant tumor which because of its anatomical location and atypical early symptoms, when diagnosed invasion and metastasis often have occurred. This requires a better understanding of the development mechanism, identifying diagnostic markers, and developing new treatment strategies.

Objective:

To study the relationship of LMP1 and Cripto-1 in nasopharyngeal carcinoma.

Methods:

The expression of LMP1 and Cripto-1 in specimens obtained from nasopharyngeal carcinoma patients (n = 42) and nasopharyngitis patients (n = 22) were examined. The expression of LMP1 and Cripto-1 in LMP1-negative and LMP1-positive (CNE1-LMP1) cells were also examined.

Results:

The expression of LMP1 and Cripto-1 was significantly higher in nasopharyngeal carcinoma than in nasopharyngitis (p < 0.05). Their expression in nasopharyngeal carcinoma with metastasis were significantly higher than that without metastasis (p < 0.05), which was correlated with TNM staging (p < 0.05). High Cripto-1 expression and high proliferation rate were seen in CNE1-LMP1 cells.

Conclusions:

The expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma is positively related. Their co-expression might contribute to the proliferation and metastasis of nasopharyngeal carcinoma.
RESUMO
Resumo

Introdução:

O carcinoma nasofaríngeo é um tumor maligno derivado do epitélio de localização anatômica recôndita e sintomas iniciais atípicos; quando diagnosticado, frequentemente invasão e metástases já ocorreram. Isso requer uma melhor compreensão do seu mecanismo de desenvolvimento, identificação dos marcadores diagnósticos e desenvolvimento de novas estratégias de tratamento.

Objetivo:

Estudar a relação de LMP1 e Cripto-1 no carcinoma nasofaríngeo.

Método:

A expressão de LMP1 e Cripto-1 em espécimes obtidos de pacientes com carcinoma de nasofaringe (n = 42) e pacientes com nasofaringite (n = 22) foi analisada. A expressão de LMP1 e Cripto-1 em células LMP1-negativas e LMP1-positivas (CNE1-LMP1) também foi analisada.

Resultados:

A expressão de LMP1 e Cripto-1 foi significantemente maior na presença de carcinoma nasofaríngeo do que na nasofaringite (p < 0,05). Sua expressão em carcinomas com metástase foi significantemente maior do que em casos sem metástase (p < 0,05), o que se correlacionou com o estadiamento TNM (p < 0,05). Uma alta expressão de Cripto-1 e alta taxa de proliferação foram observadas nas células CNE1-LMP1.

Conclusões:

A expressão de LMP1 e Cripto-1 é positivamente relacionada com carcinoma nasofaríngeo. Sua coexpressão pode ser atribuída à proliferação e metástase do tumor.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Nasopharyngeal Neoplasms / Nasopharyngeal Carcinoma Type of study: Prognostic study Limits: Humans Language: English Journal: Braz. j. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2020 Type: Article Affiliation country: China Institution/Affiliation country: Fujian Medical University/CN / Fujian Normal University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Nasopharyngeal Neoplasms / Nasopharyngeal Carcinoma Type of study: Prognostic study Limits: Humans Language: English Journal: Braz. j. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2020 Type: Article Affiliation country: China Institution/Affiliation country: Fujian Medical University/CN / Fujian Normal University/CN