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Atenolol increases dental mineralization in male offspring of treated hypertensive rats and normotensive rats
Elias, Gracieli Prado; Araujo, Heitor Ceolin; Sassaki, Kikue Takebayashi; Delbem, Alberto Carlos Botazzo; Antoniali, Cristina.
  • Elias, Gracieli Prado; Universidade Federal de Juiz de Fora. Juiz de Fora Dental School. Department of Pediatric Dentistry and Public Heatlh. Juiz de Fora. BR
  • Araujo, Heitor Ceolin; Universidade Estadual Paulista. School of Dentistry. Department of Preventive and Restorative Dentistry. Araçatuba. BR
  • Sassaki, Kikue Takebayashi; Universidade Estadual Paulista. School of Dentistry. Department of Basic Sciences. Araçatuba. BR
  • Delbem, Alberto Carlos Botazzo; Universidade Estadual Paulista. School of Dentistry. Department of Preventive and Restorative Dentistry. Araçatuba. BR
  • Antoniali, Cristina; Universidade Estadual Paulista. School of Dentistry. Department of Basic Sciences. Araçatuba. BR
Braz. oral res. (Online) ; 34: e086, 2020. tab, graf
Article in English | LILACS, BBO | ID: biblio-1132728
ABSTRACT
Abstract This study evaluates how atenolol affects dental mineralization in offspring of female spontaneously hypertensive rats (fSHR) and normotensive Wistar rats (fW). fSHR and fW were treated with atenolol (100 mg/Kg/day, orally) during pregnancy and lactation. Non-treated fSHR and fW were the control groups. Enamel and dentin hardness were analyzed (Knoop, 15 g load, 10s) in mandibular incisor teeth (IT) and molar teeth (MT) obtained from the male offspring of atenolol-treated and non-treated fWistar and fSHR. Data were analyzed by ANOVA, followed by Tukey post hoc test (p < 0.05). Atenolol reduced the arterial blood pressure (SBP) in fSHR, but it did not change the SBP in fW. The offspring of non-treated fSHR had lower enamel (IT and MT) and dentin (IT) hardness than the offspring of non-treated fW (p < 0.05). Atenolol increased enamel and dentin hardness in the IT obtained from the offspring of fSHR and fW (p<0.05), but the offspring of fSHR presented higher values (p < 0.05). Atenolol did not alter enamel width in the IT obtained from any of the groups, but it increased enamel and dentin hardness in the IT obtained from the offspring of fSHR and fW. Atenolol affected the IT obtained from the offspring of fSHR. Atenolol increased only enamel hardness in the MT obtained from the offspring of fW. In conclusion, maternal hypertension reduces tooth hard tissues, and treatment with atenolol increases tooth hardness in male offspring of hypertensive and normotensive female rats.
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Full text: Available Index: LILACS (Americas) Main subject: Hypertension Limits: Animals / Pregnancy Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR / Universidade Federal de Juiz de Fora/BR

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Full text: Available Index: LILACS (Americas) Main subject: Hypertension Limits: Animals / Pregnancy Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR / Universidade Federal de Juiz de Fora/BR