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Polymorphisms of matrix metalloproteinase-7 and -9 are associated with oral tongue squamous cell carcinoma
Nascimento, George João Ferreira do; Silva, Leorik Pereira da; Matos, Felipe Rodrigues de; Silva, Thayse Azevedo da; Medeiros, Silvia Regina Batistuzzo de; Souza, Lélia Batista de; Freitas, Roseana de Almeida.
  • Nascimento, George João Ferreira do; Universidade Federal de Campina Grande. Biological Sciences Academic Center. Patos. BR
  • Silva, Leorik Pereira da; Universidade Federal do Amazonas. Health and Biotechnology Institute. Coari. BR
  • Matos, Felipe Rodrigues de; Universidade Federal do Sergipe. Dentistry Department of Lagarto. Lagarto. BR
  • Silva, Thayse Azevedo da; Instituto Federal do Rio Grande do Norte. Parnamirim. BR
  • Medeiros, Silvia Regina Batistuzzo de; Universidade Federal do Rio Grande do Norte. Biosciences Center. Department of Cell Biology and Genetics. Natal. BR
  • Souza, Lélia Batista de; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Oral Pathology. Natal. BR
  • Freitas, Roseana de Almeida; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Oral Pathology. Natal. BR
Braz. oral res. (Online) ; 35: e019, 2021. tab
Article in English | LILACS, BBO | ID: biblio-1132747
ABSTRACT
Abstract Matrix degradation is an important event in the progression, invasion and metastasis of malignant head and neck lesions. Imbalances, mutations and polymorphisms of MMPs and their inhibitors are observed in several cancer subtypes. The aim of this study was to evaluate the association of the MMP-7 gene promoter (181 A/G) and MMP-9 (-1562 C/T) polymorphisms in oral tongue squamous cell carcinoma (OTSCC). MMP-7 (rs11568818) and MMP-9 (rs3918242) single-nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 71 cases of OTSCC. Normal tissue specimens were obtained from 60 healthy volunteers to serve as the control. The MMP-7 G allele and MMP-9 T allele were more frequent in the OTSCC group than the control group, but only when these two SNPs were taken together was a significant association found with the nodal metastasis of OTSCC (p < 0.001). Based on our results, SNPs in the promoter region of MMP-7 and MMP-9 appear to be associated with greater risk of developing OTSCC, and with a higher propensity to form metastatic tumors. In this respect, molecular studies investigating polymorphisms may be useful in predicting tumor behavior.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Tongue Neoplasms / Carcinoma, Squamous Cell / Matrix Metalloproteinase 9 / Matrix Metalloproteinase 7 Type of study: Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Federal do Rio Grande do Norte/BR / Universidade Federal de Campina Grande/BR / Universidade Federal do Amazonas/BR / Universidade Federal do Rio Grande do Norte/BR / Universidade Federal do Sergipe/BR

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Full text: Available Index: LILACS (Americas) Main subject: Tongue Neoplasms / Carcinoma, Squamous Cell / Matrix Metalloproteinase 9 / Matrix Metalloproteinase 7 Type of study: Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Federal do Rio Grande do Norte/BR / Universidade Federal de Campina Grande/BR / Universidade Federal do Amazonas/BR / Universidade Federal do Rio Grande do Norte/BR / Universidade Federal do Sergipe/BR