Evaluation of pH and residual gastric volume after colon preparation with mannitol: prospective randomized study comparing procedure performed after 3 hours versus 6 hours
Clinics
;
75: e1847, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1133435
ABSTRACT
OBJECTIVES:
Our goal was to compare the hydrogen potential (pH) and residual gastric volume (RGV) of patients undergoing colonoscopy after 3 and 6 hours of colon preparation with mannitol.METHODS:
We described a prospective randomized trial with a 5050 allocation rate of two distinct times of colonoscopy after colon preparation with 10% mannitol. We included outpatients aged over 18 years, with no history of gastric surgeries and an American Society of Anesthesiologists (ASA)-rated anesthetic risk below III. Colonoscopy was performed after upper digestive endoscopy at two different times 3 versus 6-hour after mannitol ingestion. During upper gastrointestinal endoscopy, we measured RGV and evaluated pH with a digital pH meter. Clinical trials.gov 71123317.9.3001.0065RESULTS:
We randomized a total of 100 participants to the 3 and 6-hour groups, with the patients in the 6-hour group being younger and presenting a higher body mass index (BMI). The intervention did not result in any statistically significant differences between the two groups, neither for the RGV (p=0.98) or the pH (p=0.732). However, the subgroup of patients with diabetes mellitus showed statistically significant higher RGV values in the 3-hour group. CONCLUSION There was no difference between RGV and pH values at 3 versus 6-hour after bowel preparation with mannitol, except for RGV in diabetic patients at 3 hours. As prolonged fasting protocols may result in adverse events such as dehydration and electrolyte imbalance, we can infer that colonic preparation with mannitol in shorter fasting periods, such as 3 hours, can be adopted safely and routinely.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Colonoscopy
/
Mannitol
Type of study:
Controlled clinical trial
/
Practice guideline
/
Observational study
/
Risk factors
Limits:
Adult
/
Humans
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2020
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital Alemao Oswaldo Cruz/BR
/
Universidade de Sao Paulo/BR
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