Serum interleukin-6 level is correlated with the disease activity of systemic lupus erythematosus: a meta-analysis
Clinics
;
75: e1801, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1133464
ABSTRACT
Interleukin-6 (IL-6) plays a crucial role in systemic autoimmunity and pathologic inflammation. Numerous studies have explored serum IL-6 levels in systemic lupus erythematosus (SLE) and their correlation with disease activity. Here, we performed a meta-analysis to quantitatively assess the correlation between the serum IL-6 levels and SLE activity. The PubMed and EMBASE databases were thoroughly searched for relevant studies up to September 2019. Standardized mean differences (SMDs) with 95% confidence intervals (95% CIs) were used to describe the differences between serum IL-6 levels in SLE patients and healthy controls and between those in active SLE patients and inactive SLE patients. The correlation between the serum IL-6 levels and disease activity was evaluated using Fisher's z values. A total of 24 studies involving 1817 SLE patients and 874 healthy controls were included in this meta-analysis. Serum IL-6 levels were significantly higher in SLE patients than in the healthy controls (pooled SMD 2.12, 95% CI 1.21-3.03, Active SLE patients had higher serum IL-6 levels than inactive SLE patients (pooled SMD 2.12, 95% CI 1.21-3.03). Furthermore, the pooled Fisher's z values (pooled Fisher's z=0.36, 95% CI 0.26-0.46, p<0.01) showed that there was a positive correlation between the serum IL-6 levels and SLE activity. This study suggested that serum IL-6 levels were higher in patients with SLE than in healthy controls, and they were positively correlated with disease activity when Systemic Lupus Erythematosus Disease Activity Index>4 was defined as active SLE. More homogeneous studies with large sample sizes are warranted to confirm our findings due to several limitations in our meta-analysis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Interleukin-6
/
Lupus Erythematosus, Systemic
Type of study:
Systematic reviews
Limits:
Humans
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2020
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Affiliated Southeast Hospital of Xiamen University/CN
/
Lanzhou University Second Hospital/CN
/
Sun Yat-sen University/CN
/
The Third Affiliated Hospital of Sun Yat-sen University/CN
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