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Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome
Pereira, Maria Fernanda Badue; Litvinov, Nadia; Farhat, Sylvia Costa Lima; Eisencraft, Adriana Pasmanik; Gibelli, Maria Augusta Bento Cicaroni; Carvalho, Werther Brunow de; Fernandes, Vinicius Rodrigues; Fink, Thais de Toledo; Framil, Juliana Valéria de Souza; Galleti, Karine Vusberg; Fante, Alice Lima; Fonseca, Maria Fernanda Mota; Watanabe, Andreia; Paula, Camila Sanson Yoshino de; Palandri, Giovanna Gavros; Leal, Gabriela Nunes; Diniz, Maria de Fatima Rodrigues; Pinho, João Renato Rebello; Silva, Clovis Artur; Marques, Heloisa Helena de Sousa; Rossi Junior, Alfio; Delgado, Artur Figueiredo; Andrade, Anarella Penha Meirelles de; Schvartsman, Claudio; Sabino, Ester Cerdeira; Rocha, Mussya Cisotto; Kanunfre, Kelly Aparecida; Okay, Thelma Suely; Carneiro-Sampaio, Magda Maria Sales; Jorge, Patricia Palmeira Daenekas.
  • Pereira, Maria Fernanda Badue; Universidade de Sao Paulo. Faculdade de Medicina. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Litvinov, Nadia; Universidade de Sao Paulo. Hospital das Clinicas. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Farhat, Sylvia Costa Lima; Universidade de Sao Paulo. Hospital das Clinicas. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Eisencraft, Adriana Pasmanik; Universidade de Sao Paulo. Hospital das Clinicas. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Gibelli, Maria Augusta Bento Cicaroni; Universidade de Sao Paulo. Hospital das Clinicas. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Carvalho, Werther Brunow de; Universidade de Sao Paulo. Faculdade Medicina FMUSP. Sao Paulo. BR
  • Fernandes, Vinicius Rodrigues; Universidade de Sao Paulo. Hospital das Clinicas. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Fink, Thais de Toledo; Universidade de Sao Paulo. Hospital das Clinicas. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Framil, Juliana Valéria de Souza; Universidade de Sao Paulo. Hospital das Clinicas. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Galleti, Karine Vusberg; Universidade de Sao Paulo. Faculdade de Medicina. Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Fante, Alice Lima; Universidade de Sao Paulo. Faculdade de Medicina. Hospital das Clinicas HCFMUSP. Sao Paulo. BR
  • Fonseca, Maria Fernanda Mota; Universidade de Sao Paulo. Hospital das Clinicas. Instituto de Tratamento do Cancer Infantil. Sao Paulo. BR
  • Watanabe, Andreia; Universidade de Sao Paulo. Hospital das Clinicas. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Paula, Camila Sanson Yoshino de; Universidade de Sao Paulo. Hospital das Clinicas. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Palandri, Giovanna Gavros; Universidade de Sao Paulo. Hospital das Clinicas. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Leal, Gabriela Nunes; Universidade de Sao Paulo. Hospital das Clinicas. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Diniz, Maria de Fatima Rodrigues; Universidade de Sao Paulo. Hospital das Clinicas. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Pinho, João Renato Rebello; Universidade de Sao Paulo. Hospital das Clinicas. Laboratorio de Biologia Molecular. Sao Paulo. BR
  • Silva, Clovis Artur; Universidade de Sao Paulo. Faculdade Medicina FMUSP. Sao Paulo. BR
  • Marques, Heloisa Helena de Sousa; Universidade de Sao Paulo. Hospital das Clinicas. Instituto da Crianca e do Adolescente (ICr). Sao Paulo. BR
  • Rossi Junior, Alfio; s.af
  • Delgado, Artur Figueiredo; s.af
  • Andrade, Anarella Penha Meirelles de; s.af
  • Schvartsman, Claudio; s.af
  • Sabino, Ester Cerdeira; s.af
  • Rocha, Mussya Cisotto; s.af
  • Kanunfre, Kelly Aparecida; s.af
  • Okay, Thelma Suely; s.af
  • Carneiro-Sampaio, Magda Maria Sales; s.af
  • Jorge, Patricia Palmeira Daenekas; s.af
Clinics ; 75: e2209, 2020. tab
Article in English | LILACS | ID: biblio-1133484
ABSTRACT

OBJECTIVES:

To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C).

METHODS:

This cross-sectional study included 471 samples collected from 371 patients (age<18 years) suspected of having severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study group comprised 66/371 (18%) laboratory-confirmed pediatric COVID-19 patients 61 (92.5%) patients tested positive on real-time reverse transcription-polymerase chain reaction tests for SARS-CoV-2, and 5 (7.5%) patients tested positive on serological tests. MIS-C was diagnosed according to the criteria of the Center for Disease Control.

RESULTS:

MIS-C was diagnosed in 6/66 (9%) patients. The frequencies of diarrhea, vomiting, and/or abdominal pain (67% vs. 22%, p=0.034); pediatric SARS (67% vs. 13%, p=0.008); hypoxemia (83% vs. 23%, p=0.006); and arterial hypotension (50% vs. 3%, p=0.004) were significantly higher in patients with MIS-C than in those without MIS-C. The frequencies of C-reactive protein levels >50 mg/L (83% vs. 25%, p=0.008) and D-dimer levels >1000 ng/mL (100% vs. 40%, p=0.007) and the median D-dimer, troponin T, and ferritin levels (p<0.05) were significantly higher in patients with MIS-C. The frequencies of pediatric intensive care unit admission (100% vs. 60%, p=0.003), mechanical ventilation (83% vs. 7%, p<0.001), vasoactive agent use (83% vs. 3%, p<0.001), shock (83% vs. 5%, p<0.001), cardiac abnormalities (100% vs. 2%, p<0.001), and death (67% vs. 3%, p<0.001) were also significantly higher in patients with MIS-C. Similarly, the frequencies of oxygen therapy (100% vs. 33%, p=0.003), intravenous immunoglobulin therapy (67% vs. 2%, p<0.001), aspirin therapy (50% vs. 0%, p<0.001), and current acute renal replacement therapy (50% vs. 2%, p=0.002) were also significantly higher in patients with MIS-C. Logistic regression analysis showed that the presence of MIS-C was significantly associated with gastrointestinal manifestations [odds ratio (OR)=10.98; 95%CI (95% confidence interval)=1.20-100.86; p=0.034] and hypoxemia [OR=16.85; 95%CI=1.34-211.80; p=0.029]. Further univariate analysis showed a positive association between MIS-C and death [OR=58.00; 95%CI=6.39-526.79; p<0.0001].

CONCLUSIONS:

Pediatric patients with laboratory-confirmed COVID-19 with MIS-C had a severe clinical spectrum with a high mortality rate. Our study emphasizes the importance of investigating MIS-C in pediatric patients with COVID-19 presenting with gastrointestinal involvement and hypoxemia.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pneumonia, Viral / Coronavirus Infections / Coronavirus / Pandemics Type of study: Diagnostic study / Etiology study / Observational study / Prevalence study / Risk factors Limits: Child / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Sao Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Pneumonia, Viral / Coronavirus Infections / Coronavirus / Pandemics Type of study: Diagnostic study / Etiology study / Observational study / Prevalence study / Risk factors Limits: Child / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Sao Paulo/BR