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The significance of preoperative estimated glomerular filtration rate on survival outcomes in patients who underwent radical cystectomy and non-continent urinary diversion
Sefik, Ertugrul; Celik, Serdar; Gunlusoy, Bulent; Basmaci, Ismail; Bozkurt, Ibrahim H; Degirmenci, Tansu.
  • Sefik, Ertugrul; Bozyaka Training and Research Hospital. Department of Urology. Izmir. TR
  • Celik, Serdar; Bozyaka Training and Research Hospital. Department of Urology. Izmir. TR
  • Gunlusoy, Bulent; Bozyaka Training and Research Hospital. Department of Urology. Izmir. TR
  • Basmaci, Ismail; Bozyaka Training and Research Hospital. Department of Urology. Izmir. TR
  • Bozkurt, Ibrahim H; Bozyaka Training and Research Hospital. Department of Urology. Izmir. TR
  • Degirmenci, Tansu; Bozyaka Training and Research Hospital. Department of Urology. Izmir. TR
Int. braz. j. urol ; 46(4): 566-574, 2020. tab, graf
Article in English | LILACS | ID: biblio-1134185
ABSTRACT
ABSTRACT Purpose To evaluate the influence of preoperative renal function on survival outcomes in patients who underwent radical cystectomy (RC) with non-continent urinary diversion (UD). Materials and Methods A total of 132 patients with bladder cancer who underwent RC with non-continent UD due to urothelial carcinoma from January 2006 toMarch 2017 at our tertiary referral center were retrospectively evaluated. Patients were divided into 2 groups as those with estimated glomerular filtration rate (eGFR) <60mL/min/1.73 m2 and ≥60mL/min/1.73 m2 according to preoperative eGFR levels. Patients' characteristics, preoperative clinical data, operative data, pathologic data, oncologic data and complications were compared between the groups. Results The mean age was 64.5±8.7 (range 32 - 83) years and the median follow-up was 30.9±31.7 (range 1-113) months. There were 46 patients in Group 1 and 86 patients in Group 2. There was no difference in cancer-specific mortality (45.6% for group 1 and 30.2% for group 2, p=0.078) and survival (56.8±8.3 months for group 1 and 70.5±5.9 months for group 2, p=0.087) between the groups. Overall mortality was higher (63% for group 1 and 40.7% for group 2, p=0.014) and overall survival (43.6±6.9 months for group 1 and 62.2±5.8 months for group 2, p=0.03) was lower in Group 1 compared to Group 2. Conclusions Overall mortality was higher and overall survival was lower in patients with preoperative eGFR <60mL/s. More patients had preoperative hydronephrosis with eGFR< 60mL/s.
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Full text: Available Index: LILACS (Americas) Main subject: Glomerular Filtration Rate Type of study: Observational study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Bozyaka Training and Research Hospital/TR

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Full text: Available Index: LILACS (Americas) Main subject: Glomerular Filtration Rate Type of study: Observational study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2020 Type: Article Affiliation country: Turkey Institution/Affiliation country: Bozyaka Training and Research Hospital/TR