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Endoclips as novel fiducial markers in trimodality bladder-preserving therapy of muscle-invasive bladder carcinoma: feasibility and patient outcomes
Shahbaz, Muhammad; Ammar, Asif; Wang, Yuliang; Farhaj, Zeeshan; Qiao, Liang; Niu, Jun.
  • Shahbaz, Muhammad; Shandong University. Qilu Hospital. Department of General Surgery. Jinan. CN
  • Ammar, Asif; Combined Military Hospital. Department of Urology. Kharian. PK
  • Wang, Yuliang; Weifang People´s Hospital. Department of Urology. Shandong. CN
  • Farhaj, Zeeshan; Shandong University. Shandong Provincial Hospital. Department of Cardiovascular Surgery. Jinan. CN
  • Qiao, Liang; Weifang People´s Hospital. Department of Urology. Shandong. CN
  • Niu, Jun; Shandong University. Qilu Hospital. Department of General Surgery. Jinan. CN
Int. braz. j. urol ; 47(1): 93-99, Jan.-Feb. 2021. tab, graf
Article in English | LILACS | ID: biblio-1134320
Responsible library: BR1.1
ABSTRACT
ABSTRACT

Hypothesis:

Endoclip can be used as fiducial marker in urology.

Objective:

To assess the feasibility, cost effectiveness and reliability of endoclips as novel fiducial markers in precision radiotherapy, as part of a trimodality bladder-preserving treatment (TBPT) of muscle-invasive bladder carcinoma. Materials and

Methods:

This retrospective study was performed at Weifang People's Hospital (Weifang, China) from January 2015 to June 2018. A total of 15 patients underwent TBPT. Endoclips were applied to healthy edges of the resected bladder wall as novel fiducial markers. Radio-sensitizing chemotherapy and routine precision radiotherapy were given. The number and position of the endoclips during radiotherapy sessions were monitored. Complications and tumor recurrence were analyzed.

Results:

The mean age (±standard deviation) of the patients was 67±10 years (range 46-79). There were 3 females and 12 males. Forty-nine endoclips were applied in all patients (3.3±0.8). The tumor was completely visibly resected in all patients. The number of endoclips remained the same through the planned last radiotherapy session (3.3±0.8), i.e., none were lost. All endoclips were removed after the last radiotherapy session. The average number of follow-up months was 38.9±13.2 (range 11-52). There were no procedure-related complications at discharge or follow-up. At one-year, overall recurrence-free survival was 93.3%. Two patients had recurrences at 18 months and 10 months after TBPT, respectively, and salvage radical cystectomy was performed with no further recurrences. Another patient died due to metastasis 9 months after the completion of therapy.

Conclusions:

Endoclips are reliable, safe and cost-effective as novel fiducial markers in precision-radiotherapy post-TBPT.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Urinary Bladder Neoplasms / Carcinoma Type of study: Observational study Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2021 Type: Article Affiliation country: China / Pakistan Institution/Affiliation country: Combined Military Hospital/PK / Shandong University/CN / Weifang People´s Hospital/CN

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Full text: Available Index: LILACS (Americas) Main subject: Urinary Bladder Neoplasms / Carcinoma Type of study: Observational study Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2021 Type: Article Affiliation country: China / Pakistan Institution/Affiliation country: Combined Military Hospital/PK / Shandong University/CN / Weifang People´s Hospital/CN