Adjunctive medical expulsive therapy with tamsulosin for repeated extracorporeal shock wave lithotripsy: a systematic review and meta-analysis
Int. braz. j. urol
;
47(1): 23-35, Jan.-Feb. 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1134321
ABSTRACT
ABSTRACT Purpose:
To evaluate the efficacy of adjunctive medical expulsive therapy (MET) with tamsulosin for the promotion of stone fragments clearance for repeated extracorporeal shock wave lithotripsy (ESWL). Materials andMethods:
This meta-analysis was conducted by systematic search for randomized controlled trial (RCT) studies in PubMed/Medline, Scopus, Cochrane Library, Web of Science databases in January 2020, which compared tamsulosin with either placebo or non-placebo control for repeated ESWL. The primary endpoint was stone-free rate (SFR), the second endpoints were stone clearance time and complications. The quality assessment of included studies was performed by using the Cochrane System and Jadad score.Results:
7 RCTs were included in this meta-analysis. Tamsulosin provided higher SFR (for stones larger than 1cm, OR 5.56, p=0.0003), except for patients with stones less than 1cm. For patients with renal stones (OR 2.97, p=0.0005) or upper ureteral stones (OR 3.10, p=0.004), tamsulosin can also provide a higher SFR. In addition, tamsulosin provided a shorter stone clearance time (WMD −9.40, p=0.03) and lower pain intensity (WMD=-17.01, p <0.0001) and incidences of steinstrasse (OR 0.37, p=0.0002).Conclusion:
Adjunctive MET with tamsulosin is effective in patients with specific stone size or location that received repeated ESWL. However, no well-designed RCT that used computed tomography for the detection and assessment of residual stone fragments was found. More studies with high quality and the comparison between tamsulosin and secondary ESWL are needed in the future.
Full text:
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Index:
LILACS (Americas)
Main subject:
Lithotripsy
/
Kidney Calculi
/
Ureteral Calculi
Type of study:
Controlled clinical trial
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2021
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Huazhong University of Science and Technology/CN
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