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Partial nephrectomy provides equivalent oncologic outcomes and better renal function preservation than radical nephrectomy for pathological T3a renal cell carcinoma: A meta-analysis
Deng, Huan; Fan, Yan; Yuan, Feifei; Wang, Li; Hong, Zhengdong; Zhan, Jinfeng; Zhang, Wenxiong.
  • Deng, Huan; The Second Affiliated Hospital of Nanchang University. Department of Thoracic Surgery. Nanchang. CN
  • Fan, Yan; The Second Affiliated Hospital of Nanchang University. Department of Urology. Nanchang. CN
  • Yuan, Feifei; The Second Affiliated Hospital of Nanchang University. Department of Urology. Nanchang. CN
  • Wang, Li; The Second Affiliated Hospital of Nanchang University. Department of Urology. Nanchang. CN
  • Hong, Zhengdong; The Second Affiliated Hospital of Nanchang University. Department of Urology. Nanchang. CN
  • Zhan, Jinfeng; The Second Affiliated Hospital of Nanchang University. Department of Nephrology. Nanchang. CN
  • Zhang, Wenxiong; The Second Affiliated Hospital of Nanchang University. Department of Thoracic Surgery. Nanchang. CN
Int. braz. j. urol ; 47(1): 46-60, Jan.-Feb. 2021. tab, graf
Article in English | LILACS | ID: biblio-1134331
ABSTRACT
ABSTRACT

Purpose:

Radical nephrectomy (RN) is the standard surgical type for pathological stage T3a (pT3a) renal cell carcinoma (RCC). Recently, some studies have suggested equivalence between partial nephrectomy (PN) and RN for oncologic control and have shown the benefits of PN for better renal function. We conducted this meta-analysis to assess oncologic outcomes, perioperative outcomes and renal function between two groups among patients with pT3a RCC. Materials and

methods:

PubMed, Scopus, Web of Science, Science Direct, Ovid MEDLINE, The Cochrane Library, Embase and Google Scholar were searched for eligible articles. The endpoints of the final analysis included overall survival (OS), cancer-specific survival (CSS), recurrence-free survival (RFS), surgical complications, operative time, estimated blood loss (EBL), serum creatinine and estimated glomerular filtration rate (eGFR).

Results:

Twelve studies of moderate to high quality, including 14.152 patients, were examined. PN showed superiority for renal functional preservation, providing higher eGFR (WMD=12.48mL/min; 95%CI 10.28 to 14.67; P <0.00001) and lower serum creatinine (WMD=-0.31mg/dL; 95%CI −0.40 to −0.21; P <0.00001). There were no significant differences between PN and RN regarding operative time, EBL, surgical complications, OS, RFS and CSS. Despite inherent selection bias, most pooled estimates were consistent in sensitivity analysis and subgroup analysis. More positive margins were found in the PN group (RR=2.42; 95%CI 1.25-4.68; P=0.009).

Conclusions:

PN may be more suitable for treating pT3a RCC than RN because it provides a similar survival time (OS or RFS) and superior renal function. Nevertheless, this result is still disputed, and more high-quality studies are required.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Carcinoma, Renal Cell / Kidney Neoplasms Type of study: Observational study / Systematic reviews Limits: Humans Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: The Second Affiliated Hospital of Nanchang University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Carcinoma, Renal Cell / Kidney Neoplasms Type of study: Observational study / Systematic reviews Limits: Humans Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: The Second Affiliated Hospital of Nanchang University/CN