Analysis of Adherence to Antihypertensive Drug Treatment in an Argentinean Cohort
Int. j. cardiovasc. sci. (Impr.)
;
33(3): 272-277, May-June 2020. tab
Article
in English
| LILACS
| ID: biblio-1134368
ABSTRACT
Abstract Background Adherence to antihypertensive medication is a major challenge in the management of hypertension, and non-adherence is an important barrier to effective management of hypertension. Objectives To determine the adherence rate to hypertensive drug treatment and the factors that influence non-adherence in a cohort of the Argentinean population. Methods A multicenter cross-sectional study was conducted in eight cities of Argentina. Consecutive hypertensive patients seen in general practice offices, receiving pharmacological treatment for at least six months were included. Blood pressure measurements were performed by physicians during the patient visit. The level of adherence was assessed using the Morisky questionnaire, and patients were divided into non-adherent and adherent. Continuous variables were compared using independent t-test. Categorical variables were compared using the χ2 test. To identify the variables independently associated with non-adherence, a forward stepwise binary regression logistic model was performed, and the results expressed as odds ratio (OR) with 95% of confidence interval. All tests were two-tailed, and p-values < 0.05 were considered statistically significant. Results A total of 852 individuals (52% women, 62 ± 13 years) were included. The main reason for lack of adherence was forgetfulness of medication intake and errors in the time of intake (~ 40% in both). Individuals with more cardiovascular risk factors (smoking, diabetes, dyslipidemia and previous cardiovascular events) had lower adherence to antihypertensive treatment, and considerably younger (~ five years younger). Conclusions Adherence rate to antihypertensive drug treatment in our study group was higher than the one reported in previous studies, and the main reason for non-adherence was forgetfulness of medication intake. (Int J Cardiovasc Sci. 2020; 33(3)272-277)
Full text:
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Index:
LILACS (Americas)
Main subject:
Medication Adherence
/
Hypertension
/
Antihypertensive Agents
Type of study:
Controlled clinical trial
/
Etiology study
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Observational study
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Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Argentina
Language:
English
Journal:
Int. j. cardiovasc. sci. (Impr.)
Journal subject:
Cardiology
Year:
2020
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
CONICET Tandil/AR
/
Hospital Calafate/AR
/
Hospital General de Agudos Juan A Fernandez/AR
/
Hospital Interzonal General de Agudos General San Martin/AR
/
Hospital de Santiago del Estero/AR
/
Interzonal General Hospital of Acutes Jose de San Martin/AR
/
Universidad Nacional de Rosario/AR
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