Renal tuberculosis in an imatinib-treated chronic myeloid leukemia / Tuberculose renal em paciente com leucemia mieloide crônica tratado com imatinibe
J. bras. nefrol
;
42(3): 366-369, July-Sept. 2020. graf
Article
in English, Portuguese
| LILACS
| ID: biblio-1134844
ABSTRACT
ABSTRACT Imatinib, which inhibits tyrosine kinase activity of Bcr-Abl protein, is a standard form of treatment for chronic myeloid leukemia (CML). Through its immunomodulatory effect it affects T cell function in a number of ways. It inhibits antigen-induced T cell activation and proliferation. Antigen-specific T-cells and macrophages are vital for protection against Mycobacterium tuberculosis. Here we present a case of renal tuberculosis associated with imatinib therapy in the maintenance phase of CML. With granulomatous interstitial nephritis and positive tubercular DNA on renal biopsy, the condition was successfully treated with anti-tubercular therapy. This case provides support to the hypothesis that imatinib therapy in CML increases the susceptibility to tuberculosis and strict vigilance is required to enable its early detection and treatment.
RESUMO
RESUMO O imatinibe, um inibidor da atividade da tirosina-quinase da proteína BCR-ABL, faz parte do padrão de tratamento para leucemia mieloide crônica (LMC). Por conta de seu efeito imunomodulador, o imatinibe afeta a função dos linfócitos T de várias maneiras ao inibir a sua ativação e proliferação induzidas por antígenos. Linfócitos T e macrófagos antígeno-específicos são vitais para a proteção contra o Mycobacterium tuberculosis. O presente artigo relata um caso de tuberculose renal associada a terapia com imatinibe na fase de manutenção da LMC. Com nefrite intersticial granulomatosa e positividade para DNA de M. tuberculosis na biópsia renal, o paciente foi tratado com sucesso com terapia antituberculínica. O presente caso corrobora a hipótese de que a terapia com imatinibe na LMC aumenta a suscetibilidade à tuberculose, exigindo vigilância rigorosa para permitir sua detecção e tratamento precoces.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tuberculosis, Renal
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Imatinib Mesylate
/
Antineoplastic Agents
Type of study:
Screening study
Limits:
Adult
/
Humans
/
Male
Language:
English
/
Portuguese
Journal:
J. bras. nefrol
Journal subject:
Nephrology
Year:
2020
Type:
Article
Affiliation country:
India
Institution/Affiliation country:
Dr. Ram Manohar Lohia Institute of Medical Sciences/IN
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