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Índice neutrófilo-linfocito como factor pronóstico de COVID-19 / Neutrophil to lymphocyte ratio as a prognostic marker in COVID-19
Basbus, Luis; Lapidus, Martín I; Martingano, Ignacio; Puga, María Celeste; Pollán, Javier.
  • Basbus, Luis; Hospital Italiano de Buenos Aires. Servicio de Clínica Médica. AR
  • Lapidus, Martín I; Hospital Italiano de Buenos Aires. Servicio de Clínica Médica. AR
  • Martingano, Ignacio; Hospital Italiano de Buenos Aires. Servicio de Clínica Médica. AR
  • Puga, María Celeste; Hospital Italiano de Buenos Aires. Área de Investigación en Medicina Interna. AR
  • Pollán, Javier; Hospital Italiano de Buenos Aires. Servicio de Clínica Médica. AR
Medicina (B.Aires) ; 80(supl.3): 31-36, June 2020. tab
Article in Spanish | LILACS | ID: biblio-1135188
RESUMEN
En diciembre de 2019 un nuevo coronavirus se identificó como causa de un brote de neumonía y distrés respiratorio en Wuhan, China. En marzo de 2020 fue declarado pandemia. Resulta importante conocer predictores de mala evolución para optimizar estrategias de cuidados. El índice neutrófilo-linfocito (INL) constituye un novedoso marcador pronóstico en enfermedades cardiovasculares, oncológicas e infecciosas. Este trabajo analiza su valor pronóstico en COVID-19. Se evaluó una cohorte retrospectiva de 131 pacientes con COVID-19 confirmado, entre marzo y mayo de 2020. Se analizaron las características basales de la población, la asociación del INL ≥ 3 con COVID-19 grave y la tasa de mortalidad de la enfermedad. La mediana de edad fue de 52 años, 54% fueron hombres. En 21 pacientes se encontraron criterios de gravedad, 9 de ellos requirieron ventilación mecánica. Presentó INL ≥ 3 el 81% (18/21) de los pacientes graves y el 33% (36/110) de los pacientes leves (OR = 8.74. IC del 95% 2.74-27.86; p < 0.001). La edad y la hipertensión se asociaron con enfermedad grave. La mortalidad observada en la cohorte fue del 7% (9). En 7 de los 9 pacientes fallecidos se observó un INL ≥ 3 (p = 0.03). El INL, en conjunto con otros predictores, podría usarse como un marcador pronóstico temprano dada la alta accesibilidad y el bajo costo de la prueba.
ABSTRACT
In December 2019, a new coronavirus was identified as the cause of an outbreak of pneumonia and respiratory distress in Wuhan, China. It was declared pandemic in March 2020. It is important to know predictors of poor outcomes in order to optimize the strategies of care in newly diagnosed patients. The neutrophil to lymphocyte ratio (NLR) constitutes a novel prognostic marker for oncologic, cardiovascular and infectious diseases. We aimed to assess its prognostic value in COVID-19. We evaluated a retrospective cohort of 131 patients with COVID-19 from March to May 2020. We analyzed the association of an NLR ≥ 3 with severe COVID-19, baseline characteristics of the population and the mortality rate. The median age was 52 years, and 54% were men. 21 patients presented criteria of severe disease, 9 of them required mechanical ventilation. NLR ≥ 3 was found in 81% (18/21) of severe patients and in 33% (36/110) of mild patients (OR = 8.74. 95% CI 2.74-27.86; p < 0.001). Age and hypertension were associated with severe disease. A mortality rate of 7% (9) was obtained. Seven of the 9 patients who died presented NLR ≥ 3, with a significant association between mortality and NLR ≥ 3 (p = 0.03). NLR could be used in conjunction with other predictors, as an early prognostic marker in COVID-19 given its accessibility and low cost.
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Full text: Available Index: LILACS (Americas) Main subject: Pneumonia, Viral / Lymphocytes / Biomarkers / Coronavirus Infections / Pandemics / Neutrophils Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Male Language: Spanish Journal: Medicina (B.Aires) Journal subject: Medicine Year: 2020 Type: Article Affiliation country: Argentina Institution/Affiliation country: Hospital Italiano de Buenos Aires/AR

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Full text: Available Index: LILACS (Americas) Main subject: Pneumonia, Viral / Lymphocytes / Biomarkers / Coronavirus Infections / Pandemics / Neutrophils Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Male Language: Spanish Journal: Medicina (B.Aires) Journal subject: Medicine Year: 2020 Type: Article Affiliation country: Argentina Institution/Affiliation country: Hospital Italiano de Buenos Aires/AR