Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients
Mem. Inst. Oswaldo Cruz
;
115: e200082, 2020. tab, graf
Article
in English
| LILACS, SES-SP
| ID: biblio-1135226
ABSTRACT
Respiratory failure (RF) is the main cause of hospital admission in HIV/AIDS patients. This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were slightly higher in HIV/AIDS inpatients with RF. A flow cytometry assay for reactive oxygen species (ROS) showed lower levels in platelets of these patients in relation to the healthy subjects. However, when stimulated with adrenaline, ROS levels increased in platelets and platelet-derived microparticles of HIV/AIDS inpatients, which may increase the risk of RF during HIV and tuberculosis (HIV-TB) coinfection.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Respiratory Insufficiency
/
HIV Infections
/
HIV
/
Reactive Oxygen Species
/
Cell-Derived Microparticles
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Year:
2020
Type:
Article
Institution/Affiliation country:
Fundação Oswaldo Cruz-Fiocruz/BR
/
Fundação de Medicina Tropical Heitor Vieira Dourado/BR
/
Universidade Federal do Amazonas/BR
/
Universidade do Estado do Amazonas/BR
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