Genomic and phylogenetic characterisation of an imported case of SARS-CoV-2 in Amazonas State, Brazil
Mem. Inst. Oswaldo Cruz
;
115: e200310, 2020. tab, graf
Article
in English
| LILACS, SES-SP
| ID: biblio-1135251
ABSTRACT
A new coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] is currently causing a life-threatening pandemic. In this study, we report the complete genome sequencing and genetic characterisation of a SARS-CoV-2 detected in Manaus, Amazonas, Brazil, and the protocol we designed to generate high-quality SARS-CoV-2 full genome data. The isolate was obtained from an asymptomatic carrier returning from Madrid, Spain. Nucleotide sequence analysis showed a total of nine mutations in comparison with the original human case in Wuhan, China, and support this case as belonging to the recently proposed lineage A.2. Phylogeographic analysis further confirmed the likely European origin of this case. To our knowledge, this is the first SARS-CoV-2 genome obtained from the North Brazilian Region. We believe that the information generated in this study may contribute to the ongoing efforts toward the SARS-CoV-2 emergence.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Phylogeny
/
Pneumonia, Viral
/
Coronavirus Infections
/
Betacoronavirus
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
/
Europa
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Year:
2020
Type:
Article
Institution/Affiliation country:
Fundação Oswaldo Cruz-Fiocruz/BR
/
Fundação de Vigilância em Saúde do Amazonas/BR
/
Universidade Federal do Espírito Santo/BR
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