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Chronic Periodontitis in Patients with Type 2 Diabetes: Analysis of the FokI Polymorphism and Perception of Quality of Life
Santos, Romário Correia dos; Pinho, Roberto Carlos Mourão; Cimões, Renata.
  • Santos, Romário Correia dos; Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife. BR
  • Pinho, Roberto Carlos Mourão; Federal University of Pernambuco. Department of Prosthesis and Oral and Maxillofacial Surgery. Recife. BR
  • Cimões, Renata; Federal University of Pernambuco. Department of Prosthesis and Oral and Maxillofacial Surgery. Recife. BR
Article in English | LILACS, BBO | ID: biblio-1135545
ABSTRACT
Abstract

Objective:

To analyze whether the FokI polymorphism (rs228570) present in the vitamin D receptor gene in type 2 diabetics is related to chronic periodontitis's clinical status and evaluates the influence of chronic periodontitis on the perception of quality of life. Material and

Methods:

It is a clinical and laboratory study, composed of a sample of 59 individuals with previous diagnosis of type 2 Diabetes Mellitus and chronic periodontitis, of both sexes. On clinical examination, socio-epidemiological data and quality of life of patients with the Oral Health Impact Profile (OHIP-14) were recorded and a periogram was performed. Subsequently, saliva was collected spontaneously in sterile Falcon tubes (15 ml) and stored in the freezer at -20 °C. The purification of the genetic material was done with a PROMEGA kit (Wizard®), and the polymorphism studied was FokI (rs228570), found in the vitamin D receptor promoting region, with rs 228570. After extraction of saliva DNA and purification, genotyping was performed by real-time PCR using specific allele probes (TaqMan® System).

Results:

The polymorphism of the vitamin D receptor gene was not positively associated with the severity and clinical characteristics of periodontitis, but suggested a relationship with the extent of the disease. Periodontitis also had no positive association with patients' perception of quality of life.

Conclusion:

The perception of quality of life of patients with chronic periodontitis and type 2 diabetes mellitus was compromised by the systemic condition, secondary to oral health, although some dimensions of OHIP-14 have been more frequently mentioned, such as psychological discomfort, physical pain and physical disability.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Quality of Life / Receptors, Calcitriol / Diabetes Mellitus, Type 2 / Chronic Periodontitis Type of study: Evaluation studies Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Pesqui. bras. odontopediatria clín. integr Journal subject: Dentistry Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Pernambuco/BR / Fundação Oswaldo Cruz/BR

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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Quality of Life / Receptors, Calcitriol / Diabetes Mellitus, Type 2 / Chronic Periodontitis Type of study: Evaluation studies Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Pesqui. bras. odontopediatria clín. integr Journal subject: Dentistry Year: 2020 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Pernambuco/BR / Fundação Oswaldo Cruz/BR