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Dysregulation of serum miR-1204 and its potential as a biomarker for the diagnosis and prognosis of breast cancer
Han, Suli; Li, Peng; Wang, Donghong; Yan, Hui.
  • Han, Suli; Changzhi Medical College. Heping Hospital. Department of Clinical Laboratory. Changzhi. CN
  • Li, Peng; Changzhi Medical College. Heping Hospital. Department of Clinical Laboratory. Changzhi. CN
  • Wang, Donghong; Changzhi Medical College. Heping Hospital. Department of Clinical Laboratory. Changzhi. CN
  • Yan, Hui; Changzhi Medical College. Heping Hospital. Department of Clinical Laboratory. Changzhi. CN
Rev. Assoc. Med. Bras. (1992) ; 66(6): 732-736, June 2020. tab, graf
Article in English | SES-SP, LILACS | ID: biblio-1136278
ABSTRACT
SUMMARY OBJECTIVE A previous study has reported that miR-1204 exerted oncogenic effects in breast cancer (BC). The purpose of our paper was to evaluate the expressions of tissue and serum miR-1204 in patients with BC and further investigate its biomarker potential. METHODS The expressions of tissue and serum miR-1204 were investigated by qRT-PCR in 144 BC patients and 38 healthy controls. Chi-square tests were conducted to examine the associations between miR-1204 expressions and clinicopathological factors. Then, the associations of miR-1204s level with the survival of BC patients were determined by performing the Kaplan-Meier and multivariate analysis. The receiver operating characteristics (ROC) and area under the OC curve (AUC) were obtained to validate the diagnostic values of miR-1204. RESULTS We found that the expressions of miR-1204 were increased in both tissue and serum samples from BC patients. Multivariate assays identified tissue and serum miR-1204 overexpression as an independent poor prognostic factor. In addition, ROC curve assays indicated that tissue and serum miR-1204 are potential diagnostic markers of BC. CONCLUSIONS Detection of tissue and serum miR-1204 levels could have clinical potential as a novel prognostic/diagnostic biomarker for BC patients.
RESUMO
RESUMO OBJETIVO Um estudo anterior indicou que o miR-1204 exerce efeitos oncogênicos no Câncer de Mama (CM). O objetivo deste trabalho foi avaliar as expressões de miR-1204 sérico e em tecidos em pacientes com CM e investigar o seu potencial biomarcador. METODOLOGIA As expressões de miR-1204 sérico e em tecidos foram investigadas por qRT-PCR em 144 pacientes com CM e 38 controles saudáveis. Testes qui-quadrados foram realizados para examinar as associações entre as expressões de miR-1204 e os fatores clinicopatológicos. Em seguida, as associações entre nível de miR-1204s e sobrevida de pacientes de CM foram determinadas através de análises de Kaplan-Meier e multivariadas. A Curva Característica de Operação do Receptor (ROC) e área sob a curva (AUC) foram obtidas para validar o valor diagnóstico do MIR-1204. RESULTADOS Descobrimos que as expressões do MIR-1204 estavam aumentadas em amostras de tecido e séricas de pacientes com CM. Análises multivariadas identificaram a superexpressão de miR-1204 sérico e em tecidos como um fator independente de prognóstico ruim. Além disso, as curvas ROC indicaram que o miR-1204 sérico e em tecidos é um possível marcador de diagnóstico de CM. CONCLUSÃO A detecção dos níveis MIR-1204 em tecidos e séricos pode ter potencial clínico como um novo biomarcador de prognóstico/diagnóstico para pacientes de CM.
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Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Biomarkers, Tumor / MicroRNAs Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2020 Type: Article Institution/Affiliation country: Changzhi Medical College/CN

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Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Biomarkers, Tumor / MicroRNAs Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2020 Type: Article Institution/Affiliation country: Changzhi Medical College/CN