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Effect of COVID-19 on platelet count and its indices
Güçlü, Ertugrul; Kocayigit, Havva; Okan, Hüseyin Dogus; Erkorkmaz, Unal; Yürümez, Yusuf; Yaylaci, Selcuk; Koroglu, Mehmet; Uzun, Cem; Karabay, Oguz.
  • Güçlü, Ertugrul; Sakarya University. Faculty of Medicine. Department of Infectious Diseases and Clinical Microbiology. Sakarya. TR
  • Kocayigit, Havva; Sakarya University. Training and Research Hospital. Division of Anesthesiology. Sakarya. TR
  • Okan, Hüseyin Dogus; Sakarya University. Faculty of Medicine. Department of Infectious Diseases and Clinical Microbiology. Sakarya. TR
  • Erkorkmaz, Unal; Sakarya University. Faculty of Medicine. Department of Biostatistics. Sakarya. TR
  • Yürümez, Yusuf; Sakarya University. Faculty of Medicine. Department of Emergency Medicine. Sakarya. TR
  • Yaylaci, Selcuk; Sakarya University. Faculty of Medicine. Department of Internal Medicine. Sakarya. TR
  • Koroglu, Mehmet; Sakarya University. Faculty of Medicine. Department of Medical Microbiology. Sakarya. TR
  • Uzun, Cem; Sakarya University. Faculty of Medicine. Department of Infectious Diseases and Clinical Microbiology. Sakarya. TR
  • Karabay, Oguz; Sakarya University. Faculty of Medicine. Department of Infectious Diseases and Clinical Microbiology. Sakarya. TR
Rev. Assoc. Med. Bras. (1992) ; 66(8): 1122-1127, Aug. 2020. tab
Article in English | SES-SP, LILACS | ID: biblio-1136341
ABSTRACT
SUMMARY BACKGROUND Easily accessible, inexpensive, and widely used laboratory tests that demonstrate the severity of COVID-19 are important. Therefore, in this study, we aimed to investigate the relationship between mortality in COVID-19 and platelet count, Mean Platelet Volume (MPV), and platelet distribution width. METHODS In total, 215 COVID-19 patients were included in this study. The patients were divided into two groups. Patients with room air oxygen saturation < 90% were considered as severe COVID-19, and patients with ≥90% were considered moderate COVID-19. Patient medical records and the electronic patient data monitoring system were examined retrospectively. Analyses were performed using the SPSS statistical software. A p-value <0.05 was considered significant. RESULTS The patients' mean age was 64,32 ± 16,07 years. According to oxygen saturation, 81 patients had moderate and 134 had severe COVID-19. Our findings revealed that oxygen saturation at admission and the MPV difference between the first and third days of hospitalization were significant parameters in COVID-19 patients for predicting mortality. While mortality was 8.4 times higher in patients who had oxygen saturation under 90 % at hospital admission, 1 unit increase in MPV increased mortality 1.76 times. CONCLUSION In addition to the lung capacity of patients, the mean platelet volume may be used as an auxiliary test in predicting the mortality in COVID-19 patients.
RESUMO
RESUMO OBJETIVO Testes laboratoriais de fácil acesso, baixo custo e amplamente utilizados capazes de demonstrar a gravidade da COVID-19 são importantes. Portanto, neste estudo, o nosso objetivo foi investigar a relação entre a mortalidade na COVID-19 e a contagem de plaquetas, volume plaquetário médio (VMP) e largura de distribuição de plaquetas. MÉTODOS No total, 215 pacientes com COVID-19 foram incluídos no estudo. Os pacientes foram divididos em dois grupos. Pacientes com saturação de oxigênio < 90% em ar ambiente foram considerados casos graves de COVID-19 e pacientes com valores ≥90% foram considerados casos moderados. Os registros médicos dos pacientes e o sistema eletrônico de monitoramento de dados de pacientes foram analisados retrospectivamente. As análises foram realizadas utilizando o software estatístico SPSS. Um valor de p <0,05 foi considerado significativo. RESULTADOS A média de idade dos pacientes foi de 64,32 ± 16,07 anos. Com base na saturação de oxigênio, 81 pacientes eram casos moderados e 134 tinham COVID-19 grave. Nosso estudo revelou que a saturação de oxigênio no momento da internação e a diferença nos valores de VPM entre o primeiro e terceiro dia de internação foram parâmetros significativos para predizer mortalidade de pacientes com COVID-19. A mortalidade foi 8,4 vezes maior nos pacientes com saturação abaixo de 90% no momento da internação, mas um aumento de apenas 1 unidade no valor de VPM aumentou a mortalidade 1,76 vezes. CONCLUSÃO Além da capacidade pulmonar dos pacientes, o volume plaquetário médio pode ser utilizado como um teste auxiliar para prever a mortalidade de pacientes com COVID-19.
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Full text: Available Index: LILACS (Americas) Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Aged80 / Humans Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2020 Type: Article Institution/Affiliation country: Sakarya University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Observational study / Prognostic study / Risk factors Limits: Aged / Aged80 / Humans Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2020 Type: Article Institution/Affiliation country: Sakarya University/TR