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Is the COVID-19 disease associated with de novo nephritic syndrome?
Dheir, Hamad; Sipahi, Savas; Yaylaci, Selcuk; Genc, Ahmed Cihad; Genc, Fevziye Turkoglu; Genc, Ahmed Bilal; Guçlu, Ertugrul; Muratdagi, Gurkan; Toptan, Hande; Karabay, Oguz.
  • Dheir, Hamad; Sakarya University. Faculty of Medicine. Division of Nephrology. Sakarya. TR
  • Sipahi, Savas; Sakarya University. Faculty of Medicine. Division of Nephrology. Sakarya. TR
  • Yaylaci, Selcuk; Sakarya University. Faculty of Medicine. Department of Internal Medicine. Sakarya. TR
  • Genc, Ahmed Cihad; Sakarya University. Faculty of Medicine. Department of Internal Medicine. Sakarya. TR
  • Genc, Fevziye Turkoglu; Sakarya University. Faculty of Medicine. Department of Internal Medicine. Sakarya. TR
  • Genc, Ahmed Bilal; Sakarya University. Faculty of Medicine. Department of Internal Medicine. Sakarya. TR
  • Guçlu, Ertugrul; Sakarya University. Faculty of Medicine. Department of Infection Diseases. Sakarya. TR
  • Muratdagi, Gurkan; Sakarya University. Faculty of Medicine. Department of Family Medicine. Sakarya. TR
  • Toptan, Hande; Sakarya University. Faculty of Medicine. Department of Microbiology. Sakarya. TR
  • Karabay, Oguz; Sakarya University. Faculty of Medicine. Department of Infection Diseases. Sakarya. TR
Rev. Assoc. Med. Bras. (1992) ; 66(9): 1258-1263, Sept. 2020. tab
Article in English | SES-SP, LILACS | ID: biblio-1136369
ABSTRACT
SUMMARY

INTRODUCTION:

This study aims to determine the incidence of de novo nephritic syndrome (NS) in COVID-19 patients and identify its associated factors.

METHODS:

All ward patients with COVID-19 pneumonia were investigated. After determining the inclusion and exclusion criteria, the study population was identified. The urine dipstick test and urine protein creatinine ratio (UPCR) measurements were performed. Patients with de novo NS findings, nasopharyngeal swab, and urine RT-PCR tests were performed simultaneously

RESULTS:

This descriptive cross-sectional study was conducted with 21 patients with COVID-19. The mean age of the patients was 42.2±8.8 years, and 71.4% of them were male. The mean duration of follow-up was 28.4±9.3 days. The urine RT-PCR test was positive in one patient (4.8%). Improvements were observed in hematuria by 71.4%, and proteinuria by 85.7% at the end of the follow-up. A significant decrease in the measured UPCR was found in comparison to the baseline(P=0.000). Also, improvements were recorded in the complete blood counts, inflammatory parameters, ferritin, and coagulation tests, compared to the baseline. There was a positive correlation between baseline UPCR and ferritin, and a negative correlation between baseline UPCR and sodium values

CONCLUSION:

COVID-19-induced de novo nephritic syndrome may occur mainly due to tubulointerstitial involvement and often results in spontaneous remission. However, why these findings were not present in all patients who had no comorbidities is not clear.
RESUMO
RESUMO

INTRODUÇÃO:

Este estudo tem como objetivo determinar a incidência da síndrome nefrítica de novo (SN) em pacientes com COVID-19 e identificar os fatores associados.

MÉTODOS:

Todos os pacientes da enfermaria com pneumonia por COVID-19 foram investigados. Após a determinação dos critérios de inclusão e exclusão, a população do estudo foi identificada. Foram realizadas medições do teste da vareta da urina e da razão da creatinina das proteínas na urina (UPCR).

RESULTADOS:

Este estudo transversal descritivo foi realizado com 21 pacientes com COVID-19. A idade média dos pacientes foi de 42,2±8,8 anos e 71,4% dos pacientes eram do sexo masculino. A duração média do seguimento foi de 28,4±9,3 dias. O teste de RT-PCR na urina foi positivo em um paciente (4,8%). Houve melhorias observadas na hematúria em 71,4% e na proteinúria em 85,7% no final do acompanhamento. E uma diminuição significativa na UPCR medida em comparação à linha de base (p=0,000). Além disso, foram registradas melhorias nas contagens sanguíneas completas, nos parâmetros inflamatórios, nos testes de ferritina e de coagulação, comparados aos valores basais. Houve correlação positiva entre UPCR basal e ferritina, e correlação negativa entre os valores basais de UPCR e sódio.

CONCLUSÃO:

A síndrome nefrítica de novo induzida por COVID-19 pode ocorrer principalmente devido ao envolvimento túbulo-intersticial e frequentemente resulta em remissão espontânea. No entanto, a questão de por que esses achados não se apresentaram em todos os pacientes que não apresentavam condição comórbida não é clara.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus / Kidney Diseases Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2020 Type: Article Institution/Affiliation country: Sakarya University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus / Kidney Diseases Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Rev. Assoc. Med. Bras. (1992) Year: 2020 Type: Article Institution/Affiliation country: Sakarya University/TR