Aspirin with or without statin in the treatment of endotheliitis, thrombosis, and ischemia in coronavirus disease
Rev. Soc. Bras. Med. Trop
;
53: e20200472, 2020. tab, graf
Article
in English
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1136838
ABSTRACT
Abstract INTRODUCTION:
In the genesis of coronavirus disease (COVID-19), there is a process of endotheliitis associated with thrombotic changes, no studies have reported the use of acetylsalicylic acid (ASA) as a possible therapeutic approach. Statins could potentiate the ASA therapy.METHODS:
This is a series of 14 cases with a laboratory-confirmed diagnosis of COVID-19. All patients underwent the ASA therapy. Those who had risk factors for vascular disease also underwent the high-potency statin therapy. When symptoms were totally or practically resolved, patients were discharged and advised to continue medications for a complementary time, according to the clinical evolution of each patient.RESULTS:
The mean age of monitored patients was 48.6 years. A total of 78.6% patients presented with at least one comorbidity, which could have contributed as a risk factor for a poor prognosis in the evolution of COVID-19. Four patients had secondary bacterial infections; three patients needed hospitalization. None of the cases progress to stage III, and all patients had remission of symptoms, with 100% survival.CONCLUSIONS:
the process of endothelial dysfunction in COVID-19 involves disseminated thrombosis, initially microvascular and later expansion into larger vessels. ASA could act as a secondary prophylaxis and prevent thrombosis from developing and reaching stage III of the disease. As this was a case series, we cannot provide definitive conclusions; however, this study allows us to formulate hypotheses and support clinical trials to evaluate benefits of the ASA therapy in the treatment of COVID-19.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pneumonia, Viral
/
Thrombosis
/
Aspirin
/
Coronavirus Infections
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Inflammation
/
Ischemia
Type of study:
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Year:
2020
Type:
Article
Institution/Affiliation country:
Hospital Metropolitano Sul Dom Hélder Câmara/BR
/
Universidade Federal de Pernambuco/BR
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