Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reports
Rev. Soc. Bras. Med. Trop
;
53: e20200372, 2020. graf
Article
in English
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1136859
ABSTRACT
Abstract Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. We herein report four COVID-19 cases with long-term positive viral ribonucleic acid (RNA) for about 61 days. Despite treatment with recombinant human interferon, convalescent plasma from COVID-19 patients, arbidol, etc., nucleic acid results were still positive for SARS-CoV-2. After treatment with ritonavir-boosted danoprevir (DNVr, 100/100 mg, once daily), all four patients showed two to three consecutive negative SARS-CoV-2 RNA and were thus discharged from hospital. Therefore, DNVr may be a potentially effective antiviral for COVID-19 patients with long-term positive SARS-CoV-2 RNA.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
RNA, Viral
/
Coronavirus Infections
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Year:
2020
Type:
Article
Institution/Affiliation country:
Ascletis Bioscience Co, Ltd/CN
/
Naval Medical University/CN
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