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Cost-utility analysis of interferon-free treatments for patients with early-stage genotype 1 hepatitis C virus in Brazil
Ferreira, Vinicius Lins; Leonart, Leticia Paula; Pedroso, Maria Lucia Alves; Pontarolo, Roberto.
Affiliation
  • Ferreira, Vinicius Lins; Universidade Federal do Paraná. Programa de Pós-Graduação em Ciências Farmacêuticas. Curitiba. BR
  • Leonart, Leticia Paula; Universidade Federal do Paraná. Programa de Pós-Graduação em Ciências Farmacêuticas. Curitiba. BR
  • Pedroso, Maria Lucia Alves; Universidade Federal do Paraná. Hospital de Clínicas. Serviço de Gastroenterologia. Curitiba. BR
  • Pontarolo, Roberto; Universidade Federal do Paraná. Programa de Pós-Graduação em Ciências Farmacêuticas. Curitiba. BR
Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;53: e20190594, 2020. tab, graf
Article in En | SES-SP, ColecionaSUS, LILACS | ID: biblio-1136866
Responsible library: BR1.1
ABSTRACT
Abstract INTRODUCTION We conducted a cost-utility analysis of available interferon-free treatments for patients with early-stage genotype 1 chronic hepatitis C based on a Brazilian public health system perspective. METHODS A Markov model was derived using a cohort of stage F0-F2 patients treated as recommended by the Brazilian national guidelines.

RESULTS:

Glecaprevir plus pibrentasvir was superior to all other treatments, followed by sofosbuvir plus velpatasvir. Sofosbuvir plus daclatasvir was identified as the least cost-effective option.

CONCLUSIONS:

The above findings were confirmed via probabilistic sensitivity analysis and the tested scenarios.
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Full text: 1 Index: LILACS Main subject: Antiviral Agents / Hepacivirus / Hepatitis C, Chronic / Drug Therapy, Combination Type of study: Guideline / Health_economic_evaluation / Prognostic_studies Limits: Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2020 Type: Article
Fulltext
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Full text: 1 Index: LILACS Main subject: Antiviral Agents / Hepacivirus / Hepatitis C, Chronic / Drug Therapy, Combination Type of study: Guideline / Health_economic_evaluation / Prognostic_studies Limits: Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2020 Type: Article