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Efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by Leishmania amazonensis
Antinarelli, Luciana Maria Ribeiro; Souza, Marcus Vinicius Nora de; Coelho, Eduardo Antonio Ferraz; Lima, Wallace Pacienza; Coimbra, Elaine Soares.
  • Antinarelli, Luciana Maria Ribeiro; Universidade Federal de Juiz de Fora. Campus Universitário. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora. BR
  • Souza, Marcus Vinicius Nora de; Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos-FarManguinhos. Rio de Janeiro. BR
  • Coelho, Eduardo Antonio Ferraz; Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical. Belo Horizonte. BR
  • Lima, Wallace Pacienza; Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Imunofarmacologia. Rio de Janeiro. BR
  • Coimbra, Elaine Soares; Universidade Federal de Juiz de Fora. Campus Universitário. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora. BR
Rev. Soc. Bras. Med. Trop ; 53: e20200091, 2020. graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS, SES-SP | ID: biblio-1136875
Responsible library: BR1.1
ABSTRACT
Abstract

INTRODUCTION:

The drugs currently available for leishmaniasis treatment have major limitations.

METHODS:

In vitro and in vivo studies were performed to evaluate the effect of a quinoline derivative, Hydraqui (7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline, against Leishmania amazonensis. In silico analyses of absorption, distribution, metabolism, excretion, and toxicity (ADMET) parameters were performed.

RESULTS:

Hydraqui showed significant in vitro anti-amastigote activity. Also, Hydraqui-treated mice exhibited high efficacy in lesion size (48.3%) and parasitic load (93.8%) reduction, did not cause hepatic and renal toxicity, and showed appropriate ADMET properties.

CONCLUSIONS:

Hydraqui presents a set of satisfactory criteria for its application as an antileishmanial agent.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Quinolines / Leishmania mexicana / Leishmaniasis, Cutaneous / Antiprotozoal Agents Limits: Animals Language: English Journal: Rev. Soc. Bras. Med. Trop Year: 2020 Type: Article Institution/Affiliation country: Fundação Oswaldo Cruz/BR / Universidade Federal de Juiz de Fora/BR / Universidade Federal de Minas Gerais/BR / Universidade Federal do Rio de Janeiro/BR

Full text: Available Index: LILACS (Americas) Main subject: Quinolines / Leishmania mexicana / Leishmaniasis, Cutaneous / Antiprotozoal Agents Limits: Animals Language: English Journal: Rev. Soc. Bras. Med. Trop Year: 2020 Type: Article Institution/Affiliation country: Fundação Oswaldo Cruz/BR / Universidade Federal de Juiz de Fora/BR / Universidade Federal de Minas Gerais/BR / Universidade Federal do Rio de Janeiro/BR