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Tea grape reduces abdominal aortic occlusion-induced lung injury
Hemsinli, Dogus; Ergene, Saban; Karakisi, Sedat Ozan; Mercantepe, Tolga; Tumkaya, Levent; Yilmaz, Adnan; Akyilzdiz, Kerimali.
  • Hemsinli, Dogus; Recep Tayyip Erdogan University. Faculty of Medicine. Department of Cardiovascular Surgery. Rize. TR
  • Ergene, Saban; Recep Tayyip Erdogan University. Faculty of Medicine. Department of Cardiovascular Surgery. Rize. TR
  • Karakisi, Sedat Ozan; Recep Tayyip Erdogan University. Faculty of Medicine. Department of Cardiovascular Surgery. Rize. TR
  • Mercantepe, Tolga; Recep Tayyip Erdogan University. Faculty of Medicine. Department of Histology and Embryology. Rize. TR
  • Tumkaya, Levent; Recep Tayyip Erdogan University. Faculty of Medicine. Department of Histology and Embryology. Rize. TR
  • Yilmaz, Adnan; Recep Tayyip Erdogan University. Faculty of Medicine. Department of Medical Biochemistry. Rize. TR
  • Akyilzdiz, Kerimali; Recep Tayyip Erdogan University. Health Care Services Vocational School. Department of Medical Services and Techniques. Rize. TR
Rev. bras. cir. cardiovasc ; 35(4): 512-520, July-Aug. 2020. tab, graf
Article in English | LILACS, SES-SP | ID: biblio-1137306
ABSTRACT
Abstract

Introduction:

Ischemia-associated mortality caused by aortic cross-clamps, as in ruptured abdominal aorta aneurysm surgeries, and reperfusion following their removal represent some of the main emergency conditions in cardiovascular surgery. The purpose of our study was to examine the potential protective effect of tea grape against aortic occlusion-induced lung injury using biochemical, histopathological, immunohistochemical, and quantitative analyses.

Methods:

Thirty-two male Sprague-Dawley rats were randomly assigned into four groups control (healthy), glycerol + ischemia/reperfusion (I/R) (sham), I/R, and I/R + tea grape.

Results:

Following aortic occlusion, we observed apoptotic pneumocytes, thickening in the alveolar wall, edematous areas in interstitial regions, and vascular congestion. We also observed an increase in pulmonary malondialdehyde (MDA) levels and decrease in pulmonary glutathione (GSH). However, tea grape reduced apoptotic pneumocytes, edema, vascular congestion, and MDA levels, while increased GSH levels in lung tissue.

Conclusion:

Our findings suggest that tea grape is effective against aortic occlusion-induced lung injury by reducing oxidative stress and apoptosis.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Reperfusion Injury / Vitis / Lung Injury Limits: Animals Language: English Journal: Rev. bras. cir. cardiovasc Year: 2020 Type: Article Institution/Affiliation country: Recep Tayyip Erdogan University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Reperfusion Injury / Vitis / Lung Injury Limits: Animals Language: English Journal: Rev. bras. cir. cardiovasc Year: 2020 Type: Article Institution/Affiliation country: Recep Tayyip Erdogan University/TR