Tea grape reduces abdominal aortic occlusion-induced lung injury
Rev. bras. cir. cardiovasc
;
35(4): 512-520, July-Aug. 2020. tab, graf
Article
in English
| LILACS, SES-SP
| ID: biblio-1137306
ABSTRACT
Abstract Introduction:
Ischemia-associated mortality caused by aortic cross-clamps, as in ruptured abdominal aorta aneurysm surgeries, and reperfusion following their removal represent some of the main emergency conditions in cardiovascular surgery. The purpose of our study was to examine the potential protective effect of tea grape against aortic occlusion-induced lung injury using biochemical, histopathological, immunohistochemical, and quantitative analyses.Methods:
Thirty-two male Sprague-Dawley rats were randomly assigned into four groups control (healthy), glycerol + ischemia/reperfusion (I/R) (sham), I/R, and I/R + tea grape.Results:
Following aortic occlusion, we observed apoptotic pneumocytes, thickening in the alveolar wall, edematous areas in interstitial regions, and vascular congestion. We also observed an increase in pulmonary malondialdehyde (MDA) levels and decrease in pulmonary glutathione (GSH). However, tea grape reduced apoptotic pneumocytes, edema, vascular congestion, and MDA levels, while increased GSH levels in lung tissue.Conclusion:
Our findings suggest that tea grape is effective against aortic occlusion-induced lung injury by reducing oxidative stress and apoptosis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Reperfusion Injury
/
Vitis
/
Lung Injury
Limits:
Animals
Language:
English
Journal:
Rev. bras. cir. cardiovasc
Year:
2020
Type:
Article
Institution/Affiliation country:
Recep Tayyip Erdogan University/TR
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